Leading science, pioneering therapies

Liver stem cells and regeneration group publications

2014

Fallowfield JA, Hayden AL, Snowdon VK, Aucott RL, Stutchfield BM, Mole DJ, Pellicoro A, Gordon-Walker TT, Henke A, Schrader J et al..  2014.  Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo.Hepatology. 59(4):1492-504.
Forbes SJ, Rosenthal N.  2014.  Preparing the ground for tissue regeneration: from mechanism to therapy.Nat Med. 20(8):857-69.
Forbes SJ.  2014.  Recent advances in stem cells and regenerative medicine.QJM. 107(4):251-2.
Lehwald N, Duhme C, Wildner M, Kuhn S, Fürst G, Forbes SJ, Jonas S, Robson SC, Knoefel WT, Schmelzle M et al..  2014.  HGF and SDF-1-mediated mobilization of CD133+ BMSC for hepatic regeneration following extensive liver resection.Liver Int. 34(1):89-101.
Guest RV, Boulter L, Kendall TJ, Minnis-Lyons SE, Walker R, Wigmore SJ, Sansom OJ, Forbes SJ.  2014.  Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma.Cancer Res. 74(4):1005-10.
Williams MJ, Clouston AD, Forbes SJ.  2014.  Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion.Gastroenterology. 146(2):349-56.
Tsuchiya A, Lu W-Y, Weinhold B, Boulter L, Stutchfield BM, Williams MJ, Guest RV, Minnis-Lyons SE, Mackinnon AC, Schwarzer D et al..  2014.  PolySia-NCAM modulates the formation of ductular reactions in liver injury.Hepatology.
Hsieh W-C, Mackinnon AC, Lu W-Y, Jung J, Boulter L, Henderson NC, Simpson KJ, Schotanus B, Wojtacha D, Bird TG et al..  2014.  Galectin-3 regulates hepatic progenitor cell expansion during liver injury.Gut.

2013

Mackinnon AC, Forbes SJ.  2013.  Bone marrow contributions to fibrosis.Biochim Biophys Acta. 1832(7):955-61.
Bird TG, Lu W-Y, Boulter L, Gordon-Keylock S, Ridgway RA, Williams MJ, Taube J, Thomas JA, Wojtacha D, Gambardella A et al..  2013.  Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling.Proc Natl Acad Sci U S A. 110(16):6542-7.
Stutchfield BM, Forbes SJ.  2013.  Liver sinusoidal endothelial cells in disease--and for therapy?J Hepatol. 58(1):178-80.
Boulter L, Lu W-Y, Forbes SJ.  2013.  Differentiation of progenitors in the liver: a matter of local choice.J Clin Invest. 123(5):1867-73.

2012

Pellicoro A, Aucott RL, Ramachandran P, Robson AJ, Fallowfield JA, Snowdon VK, Hartland SN, Vernon M, Duffield JS, R Benyon C et al..  2012.  Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis.Hepatology. 55(6):1965-75.
Ramachandran P, Pellicoro A, Vernon MA, Boulter L, Aucott RL, Ali A, Hartland SN, Snowdon VK, Cappon A, Gordon-Walker TT et al..  2012.  Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.Proc Natl Acad Sci U S A. 109(46):E3186-95.
Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, Pellicoro A, Ridgway RA, Seo SSoo, Spee B, van Rooijen N et al..  2012.  Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.Nat Med. 18(4):572-9.
Zhou W, Hannoun Z, Jaffray E, Medine C.N, Black JR, Greenhough S, Zhu L, Ross JA, Forbes SJ, Wilmut I et al..  2012.  SUMOylation of HNF4α regulates protein stability and hepatocyte function.J Cell Sci. 125(Pt 15):3630-5.
Forbes SJ, Newsome PN.  2012.  New horizons for stem cell therapy in liver disease.J Hepatol. 56(2):496-9.

2011

Kallis YN, Robson AJ, Fallowfield JA, Thomas HC, Alison MR, Wright NA, Goldin RD, Iredale JP, Forbes SJ.  2011.  Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response.Gut. 60(4):525-33.
Schrader J, Gordon-Walker TT, Aucott RL, Van Deemter M, Quaas A, Walsh S, Benten D, Forbes SJ, Wells RG, Iredale JP.  2011.  Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells.Hepatology. 53(4):1192-205.
Payne C, Samuel K, Pryde A, King J, Brownstein D, Schrader J, Medine C.N, Forbes SJ, Iredale JP, Newsome PN et al..  2011.  Persistence of functional hepatocyte-like cells in immune-compromised mice.Liver Int. 31(2):254-62.

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