Leading science, pioneering therapies

Developmental origins of blood stem cells and leukaemia group publications

2012

Fitch SR, Kimber GM, Wilson NK, Parker A, Mirshekar-Syahkal B, Göttgens B, Medvinsky AL, Dzierzak E, Ottersbach K.  2012.  Signaling from the sympathetic nervous system regulates hematopoietic stem cell emergence during embryogenesis.Cell Stem Cell. 11(4):554-66.

2011

Tijssen MR, Cvejic A, Joshi A, Hannah RL, Ferreira R, Forrai A, Bellissimo DC, S Oram H, Smethurst PA, Wilson NK et al..  2011.  Genome-wide analysis of simultaneous GATA1/2, RUNX1, FLI1, and SCL binding in megakaryocytes identifies hematopoietic regulators.Dev Cell. 20(5):597-609.
Robin C, Ottersbach K, Boisset J-C, Oziemlak A, Dzierzak E.  2011.  CD41 is developmentally regulated and differentially expressed on mouse hematopoietic stem cells.Blood. 117(19):5088-91.
Knezevic K, Bee T, Wilson NK, Janes ME, Kinston S, Polderdijk S, Kolb-Kokocinski A, Ottersbach K, Pencovich, iv N, Groner Y et al..  2011.  A Runx1-Smad6 rheostat controls Runx1 activity during embryonic hematopoiesis.Mol Cell Biol. 31(14):2817-26.

2010

Wilson NK, Timms RT, Kinston SJ, Cheng Y-H, S Oram H, Landry J-R, Mullender J, Ottersbach K, Göttgens B.  2010.  Gfi1 expression is controlled by five distinct regulatory regions spread over 100 kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 acting as upstream regulators in early hematopoietic cells.Mol Cell Biol. 30(15):3853-63.
Ottersbach K, Dzierzak E.  2010.  The placenta as a haematopoietic organ.Int J Dev Biol. 54(6-7):1099-106.
Göttgens B, Ferreira R, Sanchez M-J, Ishibashi S, Li J, Spensberger D, Lefevre P, Ottersbach K, Chapman M, Kinston S et al..  2010.  cis-Regulatory remodeling of the SCL locus during vertebrate evolution.Mol Cell Biol. 30(24):5741-51.
Ottersbach K, Smith A, Wood A, Göttgens B.  2010.  Ontogeny of haematopoiesis: recent advances and open questions.Br J Haematol. 148(3):343-55.
Li J, Spensberger D, Ahn JSook, Anand S, Beer PA, Ghevaert C, Chen E, Forrai A, Scott LM, Ferreira R et al..  2010.  JAK2 V617F impairs hematopoietic stem cell function in a conditional knock-in mouse model of JAK2 V617F-positive essential thrombocythemia.Blood. 116(9):1528-38.

2009

Peeters M, Ottersbach K, Bollerot K, Orelio C, de Bruijn M, Wijgerde M, Dzierzak E.  2009.  Ventral embryonic tissues and Hedgehog proteins induce early AGM hematopoietic stem cell development.Development. 136(15):2613-21.
Ottersbach K, Dzierzak E.  2009.  Analysis of the mouse placenta as a hematopoietic stem cell niche.Methods Mol Biol. 538:335-46.

2008

Pimanda JE, Chan WYI, Wilson NK, Smith AM, Kinston S, Knezevic K, Janes ME, Landry J-R, Kolb-Kokocinski A, Frampton J et al..  2008.  Endoglin expression in blood and endothelium is differentially regulated by modular assembly of the Ets/Gata hemangioblast code.Blood. 112(12):4512-22.
Landry J-R, Kinston S, Knezevic K, de Bruijn MFTR, Wilson N, Nottingham WT, Peitz M, Edenhofer F, Pimanda JE, Ottersbach K et al..  2008.  Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver.Blood. 111(6):3005-14.

2007

Durand C, Robin C, Bollerot K, Baron MH, Ottersbach K, Dzierzak E.  2007.  Embryonic stromal clones reveal developmental regulators of definitive hematopoietic stem cells.Proc Natl Acad Sci U S A. 104(52):20838-43.
Pimanda JE, Ottersbach K, Knezevic K, Kinston S, Chan WYI, Wilson NK, Landry J-R, Wood AD, Kolb-Kokocinski A, Green AR et al..  2007.  Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development.Proc Natl Acad Sci U S A. 104(45):17692-7.

2006

Robin C, Ottersbach K, Durand C, Peeters M, Vanes L, Tybulewicz V, Dzierzak E.  2006.  An unexpected role for IL-3 in the embryonic development of hematopoietic stem cells.Dev Cell. 11(2):171-80.

2005

Ottersbach K, Dzierzak E.  2005.  The murine placenta contains hematopoietic stem cells within the vascular labyrinth region.Dev Cell. 8(3):377-87.

2004

Ling K-W, Ottersbach K, van Hamburg JPiet, Oziemlak A, Tsai F-Y, Orkin SH, Ploemacher R, Hendriks RW, Dzierzak E.  2004.  GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells.J Exp Med. 200(7):871-82.

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