Leading science, pioneering therapies

Developmental origins of blood stem cells and leukaemia group publications

2019

Fitch SR, Kapeni C, Tsitsopoulou A, Wilson NK, Göttgens B, de Bruijn MF, Ottersbach K.  2019.  Gata3 targets Runx1 in the embryonic haematopoietic stem cell niche.IUBMB Life.
Ottersbach K.  2019.  Endothelial-to-haematopoietic transition: an update on the process of making blood.Biochem Soc Trans. 47(2):591-601.
Mansell E, Zareian N, Malouf C, Kapeni C, Brown N, Badie C, Baird D, Lane J, Ottersbach K, Blair A et al..  2019.  DNA damage signalling from the placenta to foetal blood as a potential mechanism for childhood leukaemia initiation.Sci Rep. 9(1):4370.

2018

Zaidan N, Ottersbach K.  2018.  The multi-faceted role of Gata3 in developmental haematopoiesis.Open Biol. 8(11)
Ottersbach K, Sanjuan-Pla A., Torres-Ruíz R., Bueno C., Velasco-Hernández T., Menendez P..  2018.  The “never-ending” mouse models for MLL-rearranged acute leukemia are still teaching usHemaSphere. 2(4)(e57)
Crosby A, Toshner MR, Southwood MR, Soon E, Dunmore BJ, Groves E, Moore S, Wright P, Ottersbach K, Bennett C et al..  2018.  Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.Pulm Circ. 8(4):2045894018801642.

2017

Malouf C, Sahm F, Kapeni C, Ottersbach K.  2017.  MiR-128a, miR-130b and miR-155 are co-drivers of t(4;11) MLL-AF4 acute lymphoblastic leukemia.Experimental Haematology 53, Supplement, page S80.
Malouf C, Ottersbach K.  2017.  Molecular processes involved in B cell acute lymphoblastic leukaemia.Cell Mol Life Sci.

2016

Barrett NA, Malouf C, Kapeni C, Bacon WA, Giotopoulos G, Jacobsen SEirik W, Huntly BJ, Ottersbach K.  2016.  Mll-AF4 Confers Enhanced Self-Renewal and Lymphoid Potential during a Restricted Window in Development.Cell Rep. 16(4):1039-54.
Mascarenhas MI, Bacon WA, Kapeni C, Fitch SR, Kimber G, Cheng SWPriscill, Li J, Green AR, Ottersbach K.  2016.  Analysis of Jak2 signaling reveals resistance of mouse embryonic hematopoietic stem cells to myeloproliferative disease mutation.Blood. 127((19)):2298-309.

2015

Rao TNageswara, Marks-Bluth J, Sullivan J, Gupta MK, Chandrakanthan V, Fitch SR, Ottersbach K, Jang YC, Piao X, Kulkarni RN et al..  2015.  High-level Gpr56 expression is dispensable for the maintenance and function of hematopoietic stem and progenitor cells in mice.Stem Cell Res. 14(3):307-22.
Marks-Bluth J, Khanna A, Chandrakanthan V, Thoms J, Bee T, Eich C, Kang YChan, Knezevic K, Qiao Q, Fitch S et al..  2015.  SMAD1 and SMAD5 Expression Is Coordinately Regulated by FLI1 and GATA2 during Endothelial Development.Mol Cell Biol. 35(12):2165-72.

2014

Barrett N.A., Kapeni C., Malouf C, Giotopoulos G., Fitch S., Bacon W.A., Huntly B., Ottersbach K.  2014.  Mll-AF4 induction during ontogeny reveals early changes in myeloid and lymphoid pontential and results in hematopoietic malignancies in adult mice.Blood 124. 21:892-892.

2013

Malouf C, Bartonicek N, Bacon W.A, Kapeni C, Bacon W, Enright A, Ottersbach K.  2013.  Deciphering the role of microRNAs in early stages of haematopoiesis.Experimental Haematology 41. 8(S38)
Diffner E, Beck D, Gudgin E, Thoms JAI, Knezevic K, Pridans C, Foster S, Goode D, Lim WKhong, Boelen L et al..  2013.  Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.Blood. 121(12):2289-300.
Mirshekar-Syahkal B, Haak E, Kimber GM, van Leusden K, Harvey K, O'Rourke J, Laborda J, Bauer SR, de Bruijn MFTR, Ferguson-Smith AC et al..  2013.  Dlk1 is a negative regulator of emerging hematopoietic stem and progenitor cells.Haematologica. 98(2):163-71.

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