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Using human induced pluripotent stem cells to treat retinal disease.

TitleUsing human induced pluripotent stem cells to treat retinal disease.
Publication TypeJournal Article
Year of Publication2013
AuthorsBorooah S, Phillips MJ, Bilican B, Wright AF, Wilmut I, Chandran S, Gamm D, Dhillon B
JournalProg Retin Eye Res
Volume37
Pagination163-81
Date Published2013 Nov
ISSN1873-1635
KeywordsHumans, Induced Pluripotent Stem Cells, Models, Biological, Regenerative Medicine, Retinal Diseases, Stem Cell Transplantation
Abstract

The eye is an ideal target for exploiting the potential of human induced pluripotent stem cell (hiPSC) technology in order to understand disease pathways and explore novel therapeutic strategies for inherited retinal disease. The aim of this article is to map the pathway from state-of-the art laboratory-based discoveries to realising the translational potential of this emerging technique. We describe the relevance and routes to establishing hiPSCs in selected models of human retinal disease. Additionally, we define pathways for applying hiPSC technology in treating currently incurable, progressive and blinding retinal disease.

DOI10.1016/j.preteyeres.2013.09.002
Alternate JournalProg Retin Eye Res
PubMed ID24104210
PubMed Central IDPMC3841575
Grant ListNIH R01 EY021218 / EY / NEI NIH HHS / United States
R01 EY021218 / EY / NEI NIH HHS / United States