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Transition of mesenchymal stem/stromal cells to endothelial cells.

TitleTransition of mesenchymal stem/stromal cells to endothelial cells.
Publication TypeJournal Article
Year of Publication2013
AuthorsCrisan M
JournalStem Cell Res Ther
Date Published2013 Aug 14
KeywordsCell Culture Techniques, Endothelial Cells, Humans, Mesenchymal Stromal Cells, Umbilical Cord

Mesenchymal stem/stromal cells (MSCs) are heterogeneous. A fraction of these cells constitute multipotent cells that can self-renew and mainly give rise to mesodermal lineage cells such as adipocytes, osteocytes and chondrocytes. The ability of MSCs to differentiate into endothelial cells remains controversial. Isolation and in vitro manipulation of MSCs before clinical application are important steps. High numbers of MSCs are needed, requiring the in vitro expansion of these clinically important cells. To this end, a well-controlled procedure for MSC isolation and maintenance in culture is necessary.

Alternate JournalStem Cell Res Ther
PubMed ID23953698
PubMed Central IDPMC3854778
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