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The transcriptional foundation of pluripotency.

TitleThe transcriptional foundation of pluripotency.
Publication TypeJournal Article
Year of Publication2009
AuthorsChambers I, Tomlinson SR
JournalDevelopment
Volume136
Issue14
Pagination2311-22
Date Published2009 Jul
ISSN0950-1991
KeywordsAnimals, Base Sequence, Binding Sites, Chromatin, DNA, Embryonic Stem Cells, Homeodomain Proteins, Humans, Macromolecular Substances, Mice, Models, Molecular, Octamer Transcription Factor-3, Pluripotent Stem Cells, SOXB1 Transcription Factors, Transcription, Genetic
Abstract

A fundamental goal in biology is to understand the molecular basis of cell identity. Pluripotent embryonic stem (ES) cell identity is governed by a set of transcription factors centred on the triumvirate of Oct4, Sox2 and Nanog. These proteins often bind to closely localised genomic sites. Recent studies have identified additional transcriptional modulators that bind to chromatin near sites occupied by Oct4, Sox2 and Nanog. This suggests that the combinatorial control of gene transcription might be fundamental to the ES cell state. Here we discuss how these observations advance our understanding of the transcription factor network that controls pluripotent identity and highlight unresolved issues that arise from these studies.

DOI10.1242/dev.024398
Alternate JournalDevelopment
PubMed ID19542351
PubMed Central IDPMC2729344
Grant List / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom