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Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage.

TitleTranscription factor heterogeneity in pluripotent stem cells: a stochastic advantage.
Publication TypeJournal Article
Year of Publication2014
AuthorsTorres-Padilla M-E, Chambers I
JournalDevelopment
Volume141
Issue11
Pagination2173-81
Date Published2014 Jun
ISSN1477-9129
KeywordsAlleles, Animals, Cell Differentiation, Cell Lineage, Cell Nucleus, Embryonic Stem Cells, Gene Expression Regulation, Developmental, Gene Regulatory Networks, Homeodomain Proteins, Humans, Mice, Models, Theoretical, Pluripotent Stem Cells, Promoter Regions, Genetic, Saccharomyces cerevisiae, Stochastic Processes, Transcription Factors, Transcription, Genetic
Abstract

When pluripotent cells are exposed to a uniform culture environment they routinely display heterogeneous gene expression. Aspects of this heterogeneity, such as Nanog expression, are linked to differences in the propensity of individual cells to either self-renew or commit towards differentiation. Recent findings have provided new insight into the underlying causes of this heterogeneity, which we summarise here using Nanog, a key regulator of pluripotency, as a model gene. We discuss the role of transcription factor heterogeneity in facilitating the intrinsically dynamic and stochastic nature of the pluripotency network, which in turn provides a potential benefit to a population of cells that needs to balance cell fate decisions.

DOI10.1242/dev.102624
Alternate JournalDevelopment
PubMed ID24866112
Grant List / / Medical Research Council / United Kingdom