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Stem cells and liver repair.

TitleStem cells and liver repair.
Publication TypeJournal Article
Year of Publication2009
AuthorsKung JWC, Forbes SJ
JournalCurr Opin Biotechnol
Volume20
Issue5
Pagination568-74
Date Published2009 Oct
ISSN1879-0429
KeywordsAnimals, Artificial Organs, Cell Differentiation, Humans, Liver, Regeneration, Stem Cell Transplantation
Abstract

The liver has considerable inherent regenerative capacity through hepatocyte division and hepatic progenitor cell proliferation. In chronic disease regeneration eventually fails and liver transplantation is the only curative treatment. Current work aims to restore liver mass and functionality either through transplantation of stem cell derived hepatocyte-like cells or by stimulating endogenous liver repair. Human embryonic stem cells (ESCs) and adult somatic cells can be differentiated into hepatocyte-like cells with potential use in drug testing, bio-artificial livers and transplantation. These cells still have some limitations in functionality, understanding further human liver development and improving tissue culture is required. The use of stem cells and their progeny in animal models of liver disease has been encouraging and stimulated clinical trials to commence.

DOI10.1016/j.copbio.2009.09.004
Alternate JournalCurr. Opin. Biotechnol.
PubMed ID19837579
Grant ListG0800455 / / Medical Research Council / United Kingdom
/ / Medical Research Council / United Kingdom