|Title||Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.|
|Publication Type||Journal Article|
|Year of Publication||1994|
|Authors||Whitworth CE, Fleming S, Cumming AD, Morton JJ, Burns NJ, Williams BC, Mullins JJ|
|Date Published||1994 Dec|
|Keywords||Animals, Animals, Genetically Modified, Blood Pressure, Disease Models, Animal, Female, Heterozygote, Humans, Hypertension, Malignant, Kidney, Male, Phenotype, Rats, Rats, Inbred Lew, Rats, Sprague-Dawley, Sodium, Dietary|
Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.
|Alternate Journal||Kidney Int.|