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Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats.

TitleSpontaneous development of malignant phase hypertension in transgenic Ren-2 rats.
Publication TypeJournal Article
Year of Publication1994
AuthorsWhitworth CE, Fleming S, Cumming AD, Morton JJ, Burns NJ, Williams BC, Mullins JJ
JournalKidney Int
Volume46
Issue6
Pagination1528-32
Date Published1994 Dec
ISSN0085-2538
KeywordsAnimals, Animals, Genetically Modified, Blood Pressure, Disease Models, Animal, Female, Heterozygote, Humans, Hypertension, Malignant, Kidney, Male, Phenotype, Rats, Rats, Inbred Lew, Rats, Sprague-Dawley, Sodium, Dietary
Abstract

Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mREN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, renal failure and evidence of renin-angiotensin system activation. It appears that introduction of an additional genetic factor or factors into a monogenic model of hypertension results in malignant phase hypertension.
Alternate JournalKidney Int.
PubMed ID7699997
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