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Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

TitleSmall vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.
Publication TypeJournal Article
Year of Publication2018
AuthorsHorsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, M Cader Z, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, I Macrae M, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams AC, Williams SCR, Work LM
JournalClin Sci (Lond)
Volume132
Issue8
Pagination851-868
Date Published2018 Apr 30
ISSN1470-8736
Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

DOI10.1042/CS20171620
Alternate JournalClin. Sci.
PubMed ID29712883
Grant ListCZB/4/517 / / Chief Scientist Office / United Kingdom
MR/L023784/1 / / Medical Research Council / United Kingdom
MR/M013553/1 / / Medical Research Council / United Kingdom
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