Leading science, pioneering therapies
CRM Publications

Skeletal and cardiac muscle pericytes: Functions and therapeutic potential.

TitleSkeletal and cardiac muscle pericytes: Functions and therapeutic potential.
Publication TypeJournal Article
Year of Publication2016
AuthorsMurray IR, Baily JE, Chen WCW, Dar A, González ZN, Jensen AR, Petrigliano FA, Deb A, Henderson NC
JournalPharmacol Ther
Date Published2016 Sep 2
ISSN1879-016X
Abstract

Pericytes are periendothelial mesenchymal cells residing within the microvasculature. Skeletal muscle and cardiac pericytes are now recognized to fulfill an increasing number of functions in normal tissue homeostasis, including contributing to microvascular function by maintaining vessel stability and regulating capillary flow. In the setting of muscle injury, pericytes contribute to a regenerative microenvironment through release of trophic factors and by modulating local immune responses. In skeletal muscle, pericytes also directly enhance tissue healing by differentiating into myofibers. Conversely, pericytes have also been implicated in the development of disease states, including fibrosis, heterotopic ossication and calcification, atherosclerosis, and tumor angiogenesis. Despite increased recognition of pericyte heterogeneity, it is not yet clear whether specific subsets of pericytes are responsible for individual functions in skeletal and cardiac muscle homeostasis and disease.

DOI10.1016/j.pharmthera.2016.09.005
Alternate JournalPharmacol. Ther.
PubMed ID27595928
Grant ListR01 HL102190 / HL / NHLBI NIH HHS / United States
R01 HL129178 / HL / NHLBI NIH HHS / United States
Publication institute
CRM