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Up-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination.

TitleUp-regulation of oligodendrocyte precursor cell alphaV integrin and its extracellular ligands during central nervous system remyelination.
Publication TypeJournal Article
Year of Publication2009
AuthorsZhao C, Fancy SPJ, Franklin RJM, ffrench-Constant C
JournalJ Neurosci Res
Volume87
Issue15
Pagination3447-55
Date Published2009 Nov 15
ISSN1097-4547
KeywordsAnimals, Demyelinating Diseases, Disease Models, Animal, Extracellular Matrix, Female, Fibronectins, Integrin alphaV, Ligands, Nerve Fibers, Myelinated, Nerve Regeneration, Oligodendroglia, Rats, Rats, Sprague-Dawley, Recovery of Function, Stem Cells, Tenascin, Up-Regulation, Vitronectin
Abstract

To determine the role of extracellular matrix molecules and their integrin ligands in CNS remyelination, we have examined in experimentally induced focal demyelinated lesions the expression of the two classes of integrins implicated in oligodendrocyte development and myelination: alpha6 laminin-binding integrins and alphaV integrins that bind a range of extracellular matrix proteins containing the -Arg-Gly-Asp- (RGD) recognition sequence. Only alphaV integrins were up-regulated during remyelination, being expressed on oligodendrocyte precursor cells during their recruitment into the lesion. Next, therefore, we examined the expression of extracellular matrix ligands for alphaV integrins and documented increased expression of tenascin-C, tenascin-R, fibronectin, and vitronectin. Taken together with our previous discovery of high levels of expression of another alphaV ligand, osteopontin, during remyelination in these lesions, our findings suggest that alphaV integrins make an important contribution to successful repair in the CNS.

DOI10.1002/jnr.22231
Alternate JournalJ. Neurosci. Res.
PubMed ID19739252
Grant List689 / / Multiple Sclerosis Society / United Kingdom
G0701476 / / Medical Research Council / United Kingdom
G0701518 / / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom