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Red blood cells from pluripotent stem cells for use in transfusion.

TitleRed blood cells from pluripotent stem cells for use in transfusion.
Publication TypeJournal Article
Year of Publication2010
AuthorsMountford JC, Olivier E, Jordanides NE, de Sousa P, Turner ML
JournalRegen Med
Volume5
Issue3
Pagination411-23
Date Published2010 May
ISSN1746-076X
KeywordsBlood Banks, Cell Differentiation, Clinical Trials as Topic, Coculture Techniques, Embryonic Stem Cells, Erythrocyte Transfusion, Erythrocytes, Hematopoiesis, Hematopoietic Stem Cells, Humans, Pluripotent Stem Cells, Regenerative Medicine
Abstract

The use of donated red blood cells in transfusion is a well-established cellular therapy. However, problems including insufficient supply, transfusion-transmitted infections and the need for immunological matching hamper even in the best services. These issues may be eliminated by using pluripotent stem cells to generate universal donor group O, Rhesus D-negative red blood cells. Human embryonic stem cells can be maintained and expanded indefinitely and can, therefore, produce the very large cell numbers required for this application. Red blood cell production is also an attractive goal for pluripotent stem cell-derived therapeutics because it is a well-characterized single cell suspension, lacking nucleated cells and with a low expression of HLA molecules. Much progress has been made; however, a number of challenges remain including scale-up, clinical effectiveness and product safety.

DOI10.2217/rme.10.22
Alternate JournalRegen Med
PubMed ID20455652
Grant ListG0300484 / / Medical Research Council / United Kingdom