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Promoting remyelination in multiple sclerosis-recent advances.

TitlePromoting remyelination in multiple sclerosis-recent advances.
Publication TypeJournal Article
Year of Publication2013
AuthorsE Münzel J, E Münzel J, Williams AC
JournalDrugs
Volume73
Issue18
Pagination2017-29
Date Published2013 Dec
ISSN0012-6667
Abstract

We review the current state of knowledge of remyelination in multiple sclerosis (MS), concentrating on advances in the understanding of the pathology and the regenerative response, and we summarise progress on the development of new therapies to enhance remyelination aimed at reducing progressive accumulation of disability in MS. We discuss key target pathways identified in experimental models, as although most identified targets have not yet progressed to the stage of being tested in human clinical trials, they may provide treatment strategies for demyelinating diseases in the future. Finally, we discuss some of the problems associated with testing this class of drugs, where they might fit into the therapeutic arsenal and the gaps in our knowledge.

DOI10.1007/s40265-013-0146-8
Alternate JournalDrugs
PubMed ID24242317
PubMed Central IDPMC3853368