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Post-translational modification by SUMO.

TitlePost-translational modification by SUMO.
Publication TypeJournal Article
Year of Publication2010
AuthorsHannoun Z, Greenhough S, Jaffray E, Hay RT, Hay DC
JournalToxicology
Volume278
Issue3
Pagination288-93
Date Published2010 Dec 30
ISSN1879-3185
KeywordsEmbryonic Stem Cells, Humans, SUMO-1 Protein, Sumoylation
Abstract

Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle regulation, gene transcription, differentiation and cellular localisation. Therefore, understanding the role of SUMOylation in cell biology may allow the development of more efficient models, important in streamlining the drug discovery process. This review will focus on protein SUMOylation and its role in stem cell and somatic cell biology.

DOI10.1016/j.tox.2010.07.013
Alternate JournalToxicology
PubMed ID20674646
Grant List / / Cancer Research UK / United Kingdom