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Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015).

TitlePolyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015).
Publication TypeJournal Article
Year of Publication2015
AuthorsVillarin BLucendo, Cameron K, Szkolnicka D, Rashidi H., Bates N, Kimber SJ, Flint O, Forbes SJ, Iredale JP, Bradley M, Hay DC
JournalAdv Healthc Mater
Volume4
Issue12
Pagination1819
Date Published2015 Aug
ISSN2192-2659
Abstract

One major obstacle to the routine deployment of stem cell-derived cells is their instability in culture. On page 1820 David C. Hay and co-workers describe the use of a synthetic polymer surface. The image shows stem cell-derived hepatocytes replated on this polyurethane surface. Importantly the cells express Zonal Occludin (green stain) at the cell surface, which indicates that the cells display elements of polarization. The blue stain is DAPI, which demarks the nucleus.

DOI10.1002/adhm.201570072
Alternate JournalAdv Healthc Mater
PubMed ID26308957
Publication institute
CRM