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The placenta as a haematopoietic organ.

TitleThe placenta as a haematopoietic organ.
Publication TypeJournal Article
Year of Publication2010
AuthorsOttersbach K, Dzierzak E
JournalInt J Dev Biol
Date Published2010
KeywordsAnimals, Female, Hematopoiesis, Hematopoietic Stem Cells, Hematopoietic System, Humans, Mice, Models, Biological, Placenta, Pregnancy

The recent description of the placenta as a tissue rich in haematopoietic stem and progenitor cells has not only opened up a whole new line of investigation into how haematopoiesis is regulated in this unique mammalian tissue, but has also resulted in the revisiting of long-standing and yet unanswered questions about the significance of having multiple haematopoietic organs during development. Due to its remarkable capacity for haematopoietic stem/progenitor cell expansion, the study of placental haematopoiesis is also of obvious clinical interest. In the following pages, we summarise what is currently known about the haematopoietic regulatory processes in the murine placenta and describe our most recent data demonstrating that the human placenta, like its murine counterpart, is also a source of haematopoietic stem and progenitor cells throughout development.

Alternate JournalInt. J. Dev. Biol.
PubMed ID20711987
Grant ListG0800784 / / Medical Research Council / United Kingdom
GR063331MA / / Wellcome Trust / United Kingdom
R37DK054077 / DK / NIDDK NIH HHS / United States
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