Leading science, pioneering therapies
CRM Publications

Perivascular multipotent progenitor cells in human organs.

TitlePerivascular multipotent progenitor cells in human organs.
Publication TypeJournal Article
Year of Publication2009
AuthorsCrisan M, Chen C-W, Corselli M, Andriolo G, Lazzari L, Péault B
JournalAnn N Y Acad Sci
Date Published2009 Sep
KeywordsAdipogenesis, Biomarkers, Cartilage, Cell Differentiation, Cell Separation, Heart Failure, Humans, Multipotent Stem Cells, Muscle Development, Osteogenesis, Pericytes

We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-Rbeta, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.

Alternate JournalAnn. N. Y. Acad. Sci.
PubMed ID19796239
Publication institute