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Oct4: the final frontier, differentiation defining pluripotency.

TitleOct4: the final frontier, differentiation defining pluripotency.
Publication TypeJournal Article
Year of Publication2013
AuthorsLivigni A, Brickman JM
JournalDev Cell
Volume25
Issue6
Pagination547-8
Date Published2013 Jun 24
ISSN1878-1551
KeywordsAnimals, Blastocyst, Embryonic Stem Cells, Endoderm, Female, Gene Expression Regulation, Developmental, Male, Octamer Transcription Factor-3, Pregnancy
Abstract

The transcription factor OCT4 is a cornerstone of pluripotency, and yet OCT4 has also been associated with differentiation in a number of contexts. Reporting in this issue of Developmental Cell, Frum et al. (2013) show that OCT4's major early activity in the blastocyst is to support primitive endoderm differentiation.

DOI10.1016/j.devcel.2013.06.002
Alternate JournalDev. Cell
PubMed ID23806612
Grant ListG0701429 / / Medical Research Council / United Kingdom