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Novel biopolymers to enhance endothelialisation of intra-vascular devices.

TitleNovel biopolymers to enhance endothelialisation of intra-vascular devices.
Publication TypeJournal Article
Year of Publication2012
AuthorsPernagallo S, Tura O, Wu M, Samuel K, Diaz-Mochon JJose, Hansen A, Zhang R, Jackson M, Padfield GJ, Hadoke PWF, Mills NL, Turner ML, Iredale JP, Hay DC, Bradley M
JournalAdv Healthc Mater
Volume1
Issue5
Pagination646-56
Date Published2012 Sep
ISSN2192-2640
KeywordsBlood Vessel Prosthesis, Cell Adhesion, Cell Proliferation, Cell Survival, Cells, Cultured, Coated Materials, Biocompatible, Endothelial Cells, Humans, Materials Testing, Stents
Abstract

Rapid endothelisation is of critical importance in the prevention of adverse remodelling after device implantation. Currently, there is a need for alternative strategies to promote re-endothelialisation for intravascular stents and vascular grafts. Using polymer microarray technology 345 polymers are comprehensively assessed and a matrix is identified that specifically supports both progenitor and mature endothelial cell activity in vitro and in vivo while minimising platelet attachment.

DOI10.1002/adhm.201200130
Alternate JournalAdv Healthc Mater
PubMed ID23184801
Grant ListFS/10/024/28266 / / British Heart Foundation / United Kingdom
/ / British Heart Foundation / United Kingdom