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New horizons for stem cell therapy in liver disease.

TitleNew horizons for stem cell therapy in liver disease.
Publication TypeJournal Article
Year of Publication2012
AuthorsForbes SJ, Newsome PN
JournalJ Hepatol
Volume56
Issue2
Pagination496-9
Date Published2012 Feb
ISSN1600-0641
KeywordsHepatocytes, Humans, Liver Cirrhosis, Liver Diseases, Liver Regeneration, Stem Cell Transplantation
Abstract

There is an increasing range of potential applications of stem cells in liver diseases, with many clinical studies already undertaken. We identify four of the main areas which we propose stem cell therapy could be a realistic aim for in the future: (1) to improve regeneration and reduce scarring in liver cirrhosis by modulating the liver's own regenerative processes, (2) to down-regulate immune mediated liver damage, (3) supplying hepatocyte-like cells (HLCs) derived from stem cells for use in extracorporeal bio-artificial liver machines, and (4) to use stem cell derived HLCs for cell transplantation to supplement or replace hepatocyte function.

DOI10.1016/j.jhep.2011.06.022
Alternate JournalJ. Hepatol.
PubMed ID21798218
Grant ListG0802577 / / Medical Research Council / United Kingdom
/ / Biotechnology and Biological Sciences Research Council / United Kingdom
/ / Medical Research Council / United Kingdom