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Mycobacterium leprae-induced demyelination: a model for early nerve degeneration.

TitleMycobacterium leprae-induced demyelination: a model for early nerve degeneration.
Publication TypeJournal Article
Year of Publication2004
AuthorsRambukkana A
JournalCurr Opin Immunol
Date Published2004 Aug
KeywordsAnimals, Axons, Demyelinating Autoimmune Diseases, CNS, Dystroglycans, Dystrophin-Associated Protein Complex, Humans, Leprosy, Mice, Mycobacterium leprae, Myelin Sheath, Schwann Cells

The molecular events that occur at the early phase of many demyelinating neurodegenerative diseases are unknown. A recent demonstration of rapid demyelination and axonal injury induced by Mycobacterium leprae provides a model for elucidating the molecular events of early nerve degeneration which might be common to neurodegenerative diseases of both infectious origin and unknown etiology. The identification of the M. leprae-targeted Schwann cell receptor, dystroglycan, and its associated molecules in myelination, demyelination and axonal functions suggests a role for these molecules in early nerve degeneration.

Alternate JournalCurr. Opin. Immunol.
PubMed ID15245748
Grant ListR01 AI45816 / AI / NIAID NIH HHS / United States
R01 NS45187 / NS / NINDS NIH HHS / United States
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