|Title||[Morphogenesis and growth potentials of organ cultures of the respiratory tract anlage of mice susceptible and resistant to pulmonary blastomogenesis].|
|Publication Type||Journal Article|
|Year of Publication||1986|
|Authors||Kolesnichenko TS, Medvinskiĭ AL|
|Date Published||1986 May-Jun|
|Keywords||Animals, Disease Susceptibility, Lung, Lung Neoplasms, Mice, Mice, Inbred A, Mice, Inbred C57BL, Morphogenesis, Organ Culture Techniques, Phenotype, Respiratory System, Time Factors|
The morphogenesis and growth potencies have been studied in the long-term organ cultures of different parts of the respiratory tract early rudiment in the mouse strains susceptible (A) and resistant (C57BL) against lung blastomogenesis. Similarities and peculiarities have been shown for the lung rudiment cells developing in vitro and in vivo. The linear differences have been established in morphogenesis and growth potencies of the proximal and distal parts of the respiratory tract rudiment. Possible importance of phenotypic differences in realization of the genetically determined sensitivity of the mouse-lung tissue to spontaneous and induced blastomogenesis is discussed.