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Molecular basis for the peripheral nerve predilection of Mycobacterium leprae.

TitleMolecular basis for the peripheral nerve predilection of Mycobacterium leprae.
Publication TypeJournal Article
Year of Publication2001
AuthorsRambukkana A
JournalCurr Opin Microbiol
Volume4
Issue1
Pagination21-7
Date Published2001 Feb
ISSN1369-5274
KeywordsAntigens, Bacterial, Cell Wall, Cytoskeletal Proteins, Dystroglycans, Glycolipids, Humans, Laminin, Leprosy, Membrane Glycoproteins, Models, Biological, Mycobacterium leprae, Peripheral Nerves, Protein Binding, Schwann Cells, Tropism
Abstract

Mycobacterium leprae, the causative organism of leprosy, has a unique predilection for Schwann cells, the glial cells of the peripheral nervous system. M. leprae invasion of Schwann cells leads to the neurological damage that underlies the sensory motor loss and subsequent deformity and disability associated with this disease. Recent studies have begun to elucidate the early events of M. leprae infection of Schwann cells on a molecular level, and the host and bacterial factors that determine the neural predilection of this bacterium. These advances have now provided novel insights into the mechanisms of bacterial interactions with host cells.

Alternate JournalCurr. Opin. Microbiol.
PubMed ID11173029
Grant ListR01 A145816 / / PHS HHS / United States
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