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Macrophage inflammatory protein-1alpha uses a novel receptor for primitive hemopoietic cell inhibition.

TitleMacrophage inflammatory protein-1alpha uses a novel receptor for primitive hemopoietic cell inhibition.
Publication TypeJournal Article
Year of Publication2001
AuthorsOttersbach K, Cook DN, Kuziel WA, Humbles A, Lu B, Gerard C, Proudfoot AE, Graham GJ
JournalBlood
Volume98
Issue12
Pagination3476-8
Date Published2001 Dec 1
ISSN0006-4971
KeywordsAnimals, Bone Marrow Cells, Cell Division, Chemokine CCL3, Chemokine CCL4, Hematopoietic Stem Cells, Macrophage Inflammatory Proteins, Mice, Mice, Knockout, Receptors, Chemokine
Abstract

Macrophage inflammatory protein-1alpha (MIP-1alpha) is a member of the chemokine family of proinflammatory mediators. In addition to its inflammatory roles, MIP-1alpha has been shown to be active as an inhibitor of primitive hemopoietic cell proliferation. Indeed, a dysfunction in this inhibitory process has been postulated to contribute to leukemogenesis. Research has been aimed at characterizing the receptor involved in cellular inhibition by MIP-1alpha. This study demonstrates that of all the beta-chemokines tested, only MIP-1alpha is capable of inhibiting primitive hemopoietic cell proliferation. Because no MIP-1alpha-specific receptors have been identified, this suggests that inhibition is mediated by an uncharacterized receptor. Further evidence for the involvement of a novel receptor in this process is the equivalent potencies of MIP-1alphaS and MIP-1alphaP variants of human MIP-1alpha and the fact that primitive cells from bone marrow derived from individual MIP-1alpha receptor null mice display a full response to MIP-1alpha inhibition.

Alternate JournalBlood
PubMed ID11719391
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