Leading science, pioneering therapies
CRM Publications

Liver regeneration - mechanisms and models to clinical application.

TitleLiver regeneration - mechanisms and models to clinical application.
Publication TypeJournal Article
Year of Publication2016
AuthorsForbes SJ, Newsome PN
JournalNat Rev Gastroenterol Hepatol
Volume13
Issue8
Pagination473-85
Date Published2016 Aug
ISSN1759-5053
Abstract

Liver regeneration has been studied for many decades and the mechanisms underlying regeneration of the normal liver following resection or moderate damage are well described. A large number of factors extrinsic (such as bile acids and circulating growth factors) and intrinsic to the liver interact to initiate and regulate liver regeneration. Less well understood, and more clinically relevant, are the factors at play when the abnormal liver is required to regenerate. Fatty liver disease, chronic scarring, prior chemotherapy and massive liver injury can all inhibit the normal programme of regeneration and can lead to liver failure. Understanding these mechanisms could enable the rational targeting of specific therapies to either reduce the factors inhibiting regeneration or directly stimulate liver regeneration. Although animal models of liver regeneration have been highly instructive, the clinical relevance of some models could be improved to bridge the gap between our in vivo model systems and the clinical situation. Likewise, modern imaging techniques such as spectroscopy will probably improve our understanding of whole-organ metabolism and how this predicts the liver's regenerative capacity. This Review describes briefly the mechanisms underpinning liver regeneration, the models used to study this process, and discusses areas in which failed or compromised liver regeneration is clinically relevant.

DOI10.1038/nrgastro.2016.97
Alternate JournalNat Rev Gastroenterol Hepatol
PubMed ID27353402
Publication institute
CRM