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[Induced hematopoietic foci in mice. I. Induction of extraskeletal hematopoietic areas using demineralized tooth matrix].

Title[Induced hematopoietic foci in mice. I. Induction of extraskeletal hematopoietic areas using demineralized tooth matrix].
Publication TypeJournal Article
Year of Publication1990
AuthorsGurevich OA, Samoĭlina NL, Medvinskiĭ AL, Gan OI
JournalGematol Transfuziol
Volume35
Issue2
Pagination7-12
Date Published1990 Feb
ISSN0234-5730
KeywordsAnimals, Bone Density, Bone Matrix, Cell Division, Colony-Forming Units Assay, Dermatologic Surgical Procedures, Fascia, Hematopoiesis, Extramedullary, Hematopoietic Stem Cells, Incisor, Kidney, Mice, Mice, Inbred C57BL, Mice, Inbred CBA
Abstract

Conditions of formation of induced osteo-hemopoietic foci in mice, in response to ectopic implantation to them of homologous demineralized tooth matrix, have been studied. It is shown that the hemopoietic tissue of the induced foci is similar to the bone marrow of the skeletal bones by the morphological parameters and cellular composition; differentiation of precursor cells takes place in all three directions of myelopoiesis. Induced foci formation under the capsule of the kidney occurs much later (after 5-8 months) than under the skin of muscular fascia (1-1.5 months). The induced hemopoietic foci functioning continues at least for one year.

Alternate JournalGematol Transfuziol
PubMed ID2332137
Publication institute
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