|Title||IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions.|
|Publication Type||Journal Article|
|Year of Publication||2017|
|Authors||Zandee SElizabeth, O'Connor RAnthony, Mair I, Leech MDawn, Williams AC, Anderton SMark|
|Journal||Immunol Cell Biol|
|Date Published||2017 Feb 07|
CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3(+) cells in the brains of MS patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function.Immunology and Cell Biology advance online publication, 7 February 2017; doi:10.1038/icb.2017.3.
|Alternate Journal||Immunol. Cell Biol.|