|Title||How does Mycobacterium leprae target the peripheral nervous system?|
|Publication Type||Journal Article|
|Year of Publication||2000|
|Date Published||2000 Jan|
|Keywords||Cytoskeletal Proteins, Dystroglycans, Humans, Laminin, Leprosy, Membrane Glycoproteins, Mycobacterium leprae, Myelin Sheath, Peripheral Nerves, Peripheral Nervous System Diseases, Protein Isoforms, Protein Structure, Tertiary, Schwann Cells|
Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules.
|Alternate Journal||Trends Microbiol.|
|Grant List||R0I A145816 / / PHS HHS / United States|