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How does Mycobacterium leprae target the peripheral nervous system?

TitleHow does Mycobacterium leprae target the peripheral nervous system?
Publication TypeJournal Article
Year of Publication2000
AuthorsRambukkana A
JournalTrends Microbiol
Date Published2000 Jan
KeywordsCytoskeletal Proteins, Dystroglycans, Humans, Laminin, Leprosy, Membrane Glycoproteins, Mycobacterium leprae, Myelin Sheath, Peripheral Nerves, Peripheral Nervous System Diseases, Protein Isoforms, Protein Structure, Tertiary, Schwann Cells

Mycobacterium leprae has the capacity to invade the peripheral nervous system and cause neuropathy. The molecular mechanisms responsible have remained unknown until recently. Identification of the endoneurial laminin-2 isoform and its receptor alpha-dystroglycan as neural targets of M. leprae has not only opened up a new area of scientific inquiry into the pathogenesis of neurological damage in leprosy, but has also revealed unexpected biological properties of these important host molecules.

Alternate JournalTrends Microbiol.
PubMed ID10637640
Grant ListR0I A145816 / / PHS HHS / United States
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