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Gene targeting and synaptic plasticity.

TitleGene targeting and synaptic plasticity.
Publication TypeJournal Article
Year of Publication1994
AuthorsGrant SG
JournalCurr Opin Neurobiol
Date Published1994 Oct
KeywordsAnimals, Behavior, Animal, Gene Targeting, Humans, Learning, Mice, Mice, Knockout, Models, Neurological, Mutation, Nerve Tissue Proteins, Neuronal Plasticity, Neurons, Protein Kinases, Receptors, N-Methyl-D-Aspartate, Second Messenger Systems, Synapses, Synaptic Vesicles

Gene targeting is revealing new molecular functions by creating very specific developmental, physiological and behavioral perturbations, and providing new insights into biochemical pathways underlying synaptic plasticity. Recent studies of mice carrying mutations in genes thought to be involved in modulating synaptic transmission have been subject to integrated biochemical, physiological and behavioral analyses.

Alternate JournalCurr. Opin. Neurobiol.
PubMed ID7849524