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Galectin-3 is expressed in the notochord, developing bones, and skin of the postimplantation mouse embryo.

TitleGalectin-3 is expressed in the notochord, developing bones, and skin of the postimplantation mouse embryo.
Publication TypeJournal Article
Year of Publication1995
AuthorsFowlis D, Colnot C, Ripoche MA, Poirier F
JournalDev Dyn
Volume203
Issue2
Pagination241-51
Date Published1995 Jun
ISSN1058-8388
KeywordsAnimals, Antigens, Differentiation, Bone and Bones, Embryo, Mammalian, Embryonic Development, Female, Galectin 3, Mice, Notochord, Pregnancy, Skin, Tissue Distribution
Abstract

The galectins are a family of low molecular weight, calcium-independent mammalian carbohydrate binding proteins that exhibit specificity for beta-galactoside derivatives. We have examined the expression pattern of galectin-3 in the developing mouse embryo by in situ hybridisation and immunohistochemistry. In the embryo proper, galectin-3 message and protein are first detected in notochord, starting from 8.5 days post coitum (dpc), and persist until this structure disappears. Galectin-3 is later found in cartilage primordia and in developing skin from 13.5 dpc. This very restricted and dynamic pattern suggests that galectin-3 may participate in the establishment and/or maintenance of notochord as well as the formation of cartilage and differentiation of skin. Finally, we find that galectin-3, which is identical to the macrophage marker Mac-2, is also expressed in embryonic macrophages.

DOI10.1002/aja.1002030211
Alternate JournalDev. Dyn.
PubMed ID7655085