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Expression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells.

TitleExpression of CD1d molecules by human schwann cells and potential interactions with immunoregulatory invariant NK T cells.
Publication TypeJournal Article
Year of Publication2006
AuthorsIm JS, Tapinos N, Chae G-T, Illarionov PA, Besra GS, DeVries GH, Modlin RL, Sieling PA, Rambukkana A, Porcelli SA
JournalJ Immunol
Volume177
Issue8
Pagination5226-35
Date Published2006 Oct 15
ISSN0022-1767
KeywordsAntigens, CD1, Antigens, CD1d, Cell Communication, Cells, Cultured, Coculture Techniques, Cytokines, Galactosylceramides, Humans, Immunity, Inflammation, Killer Cells, Natural, Nervous System Diseases, Schwann Cells, T-Lymphocytes
Abstract

CD1d-restricted NKT cells expressing invariant TCR alpha-chains (iNKT cells) produce both proinflammatory and anti-inflammatory cytokines rapidly upon activation, and are believed to play an important role in both host defense and immunoregulation. To address the potential implications of iNKT cell responses for infectious or inflammatory diseases of the nervous system, we investigated the expression of CD1d in human peripheral nerve. We found that CD1d was expressed on the surface of Schwann cells in situ and on primary or immortalized Schwann cell lines in culture. Schwann cells activated iNKT cells in a CD1d-dependent manner in the presence of alpha-galactosylceramide. Surprisingly, the cytokine production of iNKT cells stimulated by alpha-galactosylceramide presented by CD1d+ Schwann cells showed a predominance of Th2-associated cytokines such as IL-5 and IL-13 with a marked deficiency of proinflammatory Th1 cytokines such as IFN-gamma or TNF-alpha. Our findings suggest a mechanism by which iNKT cells may restrain inflammatory responses in peripheral nerves, and raise the possibility that the expression of CD1d by Schwann cells could be relevant in the pathogenesis of infectious and inflammatory diseases of the peripheral nervous system.

Alternate JournalJ. Immunol.
PubMed ID17015708
Grant List072021/Z/03/Z / / Wellcome Trust / United Kingdom
AI 051519 / AI / NIAID NIH HHS / United States
AI 064424 / AI / NIAID NIH HHS / United States
AI 45816 / AI / NIAID NIH HHS / United States
AI 45889 / AI / NIAID NIH HHS / United States
AI 51391 / AI / NIAID NIH HHS / United States
AR 40312 / AR / NIAMS NIH HHS / United States
CA 133330 / CA / NCI NIH HHS / United States
G0400421 / / Medical Research Council / United Kingdom
NS 45187 / NS / NINDS NIH HHS / United States
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