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EVA regulates thymic stromal organisation and early thymocyte development.

TitleEVA regulates thymic stromal organisation and early thymocyte development.
Publication TypeJournal Article
Year of Publication2007
AuthorsDeMonte L, Porcellini S, Tafi E, Sheridan JM, Gordon J, Depreter MGL, Blair NF, Panigada M, Sanvito F, Merati B, Albientz A, Barthlott T, Ozmen L, C Blackburn C, Guttinger M
JournalBiochem Biophys Res Commun
Volume356
Issue2
Pagination334-40
Date Published2007 May 4
ISSN0006-291X
KeywordsAnimals, Cell Adhesion Molecules, Gene Expression Regulation, Developmental, Mice, Mice, Inbred C57BL, Mice, Transgenic, T-Lymphocyte Subsets, Thymus Gland
Abstract

Epithelial V-like antigen (EVA) is an immunoglobulin-like adhesion molecule identified in a screen for molecules developmentally regulated at the DN to DP progression in thymocyte development. We show that EVA is expressed during the early stages of thymus organogenesis in both fetal thymic epithelia and T cell precursors, and is progressively downregulated from day 16.5 of embryonic development. In the postnatal thymus, EVA expression is restricted to epithelial cells and is distributed throughout both cortical and medullary thymic regions. Transgenic overexpression of EVA in the thymus cortex resulted in a modified stromal environment, which elicited an increase in organ size and absolute cell number. Although peripheral T lymphocyte numbers are augmented throughout life, no imbalance either in the repertoire, or in the different T cell subsets was detected. Collectively, these data suggest a role for EVA in structural organisation of the thymus and early lymphocyte development.

DOI10.1016/j.bbrc.2007.02.131
Alternate JournalBiochem. Biophys. Res. Commun.
PubMed ID17362876
Grant ListE.0797 / / Telethon / Italy