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Endoscopic sensing of alveolar pH.

TitleEndoscopic sensing of alveolar pH.
Publication TypeJournal Article
Year of Publication2017
AuthorsChoudhury D, Tanner MG, McAughtrie S, Yu F, Mills B, Choudhary TR, Seth S, Craven TH, Stone JM, Mati IK, Campbell CJ, Bradley M, Williams CKI, Dhaliwal K, Birks TA, Thomson RR
JournalBiomed Opt Express
Volume8
Issue1
Pagination243-259
Date Published2017 Jan 01
ISSN2156-7085
Abstract

Previously unobtainable measurements of alveolar pH were obtained using an endoscope-deployable optrode. The pH sensing was achieved using functionalized gold nanoshell sensors and surface enhanced Raman spectroscopy (SERS). The optrode consisted of an asymmetric dual-core optical fiber designed for spatially separating the optical pump delivery and signal collection, in order to circumvent the unwanted Raman signal generated within the fiber. Using this approach, we demonstrate a ~100-fold increase in SERS signal-to-fiber background ratio, and demonstrate multiple site pH sensing with a measurement accuracy of ± 0.07 pH units in the respiratory acini of an ex vivo ovine lung model. We also demonstrate that alveolar pH changes in response to ventilation.

DOI10.1364/BOE.8.000243
Alternate JournalBiomed Opt Express
PubMed ID28101415
PubMed Central IDPMC5231296
Grant ListG0901697 / / Medical Research Council / United Kingdom
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