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Effects of thyroid hormone on embryonic oligodendrocyte precursor cell development in vivo and in vitro.

TitleEffects of thyroid hormone on embryonic oligodendrocyte precursor cell development in vivo and in vitro.
Publication TypeJournal Article
Year of Publication1997
AuthorsAhlgren SC, Wallace H, Bishop J, Neophytou C, Raff MC
JournalMol Cell Neurosci
Volume9
Issue5-6
Pagination420-32
Date Published1997
ISSN1044-7431
KeywordsAnimals, Animals, Newborn, Axons, Cell Differentiation, Cell Division, Cells, Cultured, Embryo, Mammalian, Mice, Mice, Inbred C57BL, Mice, Inbred CBA, Mice, Transgenic, Oligodendroglia, Optic Nerve, Rats, Rats, Sprague-Dawley, Stem Cells, Thyroid Hormones, Time Factors, Tretinoin
Abstract

The oligodendrocyte precursor cell divides a limited number of times before terminal differentiation. The timing of differentiation depends on both intracellular mechanisms and extracellular signals, including mitogens that stimulate proliferation and signals such as thyroid hormone (TH) and retinoic acid (RA) that help trigger the cells to stop dividing and differentiate. We show here that, both in vivo and in vitro, TH is required for the normal development of rodent optic nerve oligodendrocytes, although in its absence some oligodendrocyte development still occurs, perhaps promoted by signals from axons. We also demonstrate that TH from both mother and pup plays a part in oligodendrocyte development in vivo. Finally, we show that precursors in embryonic nerve cultures differ from those in postnatal cultures in two ways: they respond much better to TH than to RA, and they respond more slowly to TH, suggesting that oligodendrocyte precursor cells mature during their early development.

DOI10.1006/mcne.1997.0631
Alternate JournalMol. Cell. Neurosci.
PubMed ID9361279