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DNA electrophoresis: historical and theoretical perspectives.

TitleDNA electrophoresis: historical and theoretical perspectives.
Publication TypeJournal Article
Year of Publication2013
AuthorsRoberts GA, Dryden DTF
JournalMethods Mol Biol
Volume1054
Pagination1-9
Date Published2013
ISSN1940-6029
KeywordsDNA, Electrophoresis, Agar Gel, Electrophoresis, Gel, Pulsed-Field, Humans, Sepharose
Abstract

The technique of gel electrophoresis is now firmly established as a routine laboratory method for analyzing DNA. Here, we describe the development of the methodology as well as a brief explanation of how the technique works. There is a short introduction to pulsed-field agarose gel electrophoresis, which represents a critical advancement in the method that facilitates the analysis of very large fragments of DNA. Finally, theoretical considerations are included.

DOI10.1007/978-1-62703-565-1_1
Alternate JournalMethods Mol. Biol.
PubMed ID23913282
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