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Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.

TitleDiscovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation.
Publication TypeJournal Article
Year of Publication2015
AuthorsCeliz AD, Smith JGW, Patel AK, Hook AL, Rajamohan D, George VT, Flatt L, Patel MJ, Epa VC, Singh T, Langer R, Anderson DG, Allen ND, Hay DC, Winkler DA, Barrett DA, Davies MC, Young LE, Denning C, Alexander MR
JournalAdv Mater
Date Published2015 Jun 1
ISSN1521-4095
Abstract

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.

DOI10.1002/adma.201501351
Alternate JournalAdv. Mater. Weinheim
PubMed ID26033422
Publication institute
CRM