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Differentiation of progenitors in the liver: a matter of local choice.

TitleDifferentiation of progenitors in the liver: a matter of local choice.
Publication TypeJournal Article
Year of Publication2013
AuthorsBoulter L, Lu W-Y, Forbes SJ
JournalJ Clin Invest
Date Published2013 May 1
KeywordsAnimals, Cell Cycle, Cell Differentiation, Cell Lineage, Hepatectomy, Humans, Inflammation, Ligands, Liver, Liver Neoplasms, Liver Transplantation, Living Donors, Mice, Mitosis, Neoplasms, Rats, Signal Transduction, Stem Cells

The liver is a complex organ that requires multiple rounds of cell fate decision for development and homeostasis throughout the lifetime. During the earliest phases of organogenesis, the liver acquires a separate lineage from the pancreas and the intestine, and subsequently, the liver bud must appropriately differentiate to form metabolic hepatocytes and cholangiocytes for proper hepatic physiology. In addition, throughout life, the liver is bombarded with chemical and pathological insults, which require the activation and correct differentiation of adult progenitor cells. This Review seeks to provide an overview of the complex signaling relationships that allow these tightly regulated processes to occur.

Alternate JournalJ. Clin. Invest.
PubMed ID23635784
PubMed Central IDPMC3635730
Grant ListG1000868 / / Medical Research Council / United Kingdom
/ / Cancer Research UK / United Kingdom
/ / Medical Research Council / United Kingdom
/ / Wellcome Trust / United Kingdom