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Deriving functional hepatocytes from pluripotent stem cells.

TitleDeriving functional hepatocytes from pluripotent stem cells.
Publication TypeJournal Article
Year of Publication2014
AuthorsSzkolnicka D, Farnworth SL, Lucendo-Villarin B, Hay DC
JournalCurr Protoc Stem Cell Biol
Volume30
Pagination1G.5.1-1G.5.12
Date Published2014
ISSN1938-8969
Abstract

Despite major progress in the management of human liver disease, the only cure for a critically failing organ is liver transplantation. While a highly successful approach, the use of cadaveric organs as a routine treatment option is severely limited by organ availability. Therefore, the use of cell-based therapies has been explored to provide support for the failing liver. In addition to developing new treatments, there is also an imperative to develop better human models 'in a dish'. Such approaches will undoubtedly lead to a better understanding of the disease process, offering new treatment or preventative strategies. With both approaches in mind, we have developed robust hepatocyte differentiation methodologies for use with pluripotent stem cells. Importantly, our procedure is highly efficient (∼90%) and delivers active, drug-inducible, and predictive human hepatocyte populations. Curr. Protoc. Stem Cell Biol. 30:1G.5.1-1G.5.12. © 2014 by John Wiley & Sons, Inc.

DOI10.1002/9780470151808.sc01g05s30
Alternate JournalCurr Protoc Stem Cell Biol
PubMed ID25081564
Publication institute
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