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Deriving and identifying hepatocytes from embryonic stem cells.

TitleDeriving and identifying hepatocytes from embryonic stem cells.
Publication TypeJournal Article
Year of Publication2006
AuthorsWatt AJ, Forrester LM
JournalStem Cell Rev
Date Published2006
KeywordsAnimals, Cell Differentiation, Embryonic Stem Cells, Hepatocytes, Mice

The generation of hepatocytes from embryonic stem cells (ESCs) holds considerable promise for basic and applied research. However, the unequivocal identification of hepatocytes in ESC differentiation strategies has been hampered by a lack of hepatocyte-specific markers. Recent studies are beginning to address this issue with the identification of hepatocyte-specific genes and the production of hepatocytes from intermediate cell types like definitive endoderm. Assuming the successful identification of ESC-derived hepatocytes, the next challenge will be in balancing the proliferation and differentiation of these cells in order to generate usable numbers of functional hepatocytes in vitro.

Alternate JournalStem Cell Rev
PubMed ID17142882