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Control of autoimmunity by "epitope theft".

TitleControl of autoimmunity by "epitope theft".
Publication TypeJournal Article
Year of Publication2005
AuthorsKranc KR, Taylor AM, Willcox N, Fugger L
JournalTrends Mol Med
Date Published2005 Jan
KeywordsAnimals, Antigen-Presenting Cells, Antigens, CD8, Autoimmune Diseases, Autoimmunity, Histocompatibility Antigens Class I, Humans, Immunodominant Epitopes, Multiple Sclerosis, T-Lymphocytes

We all possess T cells with autoaggressive potential. Knowledge of their regulation is crucial for elucidating pathogenetic pathways and designing effective treatments for autoimmune diseases. A novel mechanism of T-cell silencing--in an autoimmune model--has recently been identified and is termed "epitope theft". The "thieves" are naive CD8+ T cells, which apparently "steal" MHC-class-I-antigen complexes from antigen-presenting cells (APCs). The deprived APCs can no longer activate other potentially pathogenic naive CD8+ T cells that are specific for the same epitope. This phenomenon is a previously unrecognized antigen-specific mode of protection against autoimmunity.

Alternate JournalTrends Mol Med
PubMed ID15649815
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