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Contribution of neural crest-derived cells in the embryonic and adult thymus.

TitleContribution of neural crest-derived cells in the embryonic and adult thymus.
Publication TypeJournal Article
Year of Publication2008
AuthorsFoster K, Sheridan JM, Veiga-Fernandes H, Roderick K, Pachnis V, Adams R, C Blackburn C, Kioussis D, Coles M
JournalJ Immunol
Volume180
Issue5
Pagination3183-9
Date Published2008 Mar 1
ISSN0022-1767
KeywordsAnimals, Cell Aging, Cell Differentiation, Embryo, Mammalian, Embryonic Stem Cells, Female, Fetal Development, Genes, Reporter, Luminescent Proteins, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neural Crest, Thymus Gland
Abstract

Neural crest (NC)-derived mesenchyme has previously been shown to play an important role in the development of fetal thymus. Using Wnt1-Cre and Sox10-Cre mice crossed to Rosa26(eYfp) reporter mice, we have revealed NC-derived mesenchymal cells in the adult murine thymus. We report that NC-derived cells infiltrate the thymus before day 13.5 of embryonic development (E13.5) and differentiate into cells with characteristics of smooth muscle cells associated with large vessels, and pericytes associated with capillaries. In the adult organ at 3 mo of age, these NC-derived perivascular cells continue to be associated with the vasculature, providing structural support to the blood vessels and possibly regulating endothelial cell function.

Alternate JournalJ. Immunol.
PubMed ID18292542
Grant ListG0300058 / / Medical Research Council / United Kingdom
G0601156 / / Medical Research Council / United Kingdom
MC_U117512796 / / Medical Research Council / United Kingdom
MC_U117537087 / / Medical Research Council / United Kingdom
/ / Cancer Research UK / United Kingdom
/ / Medical Research Council / United Kingdom