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Construction of a functional thymic microenvironment from pluripotent stem cells for the induction of central tolerance.

TitleConstruction of a functional thymic microenvironment from pluripotent stem cells for the induction of central tolerance.
Publication TypeJournal Article
Year of Publication2015
AuthorsBredenkamp N, Jin X, Liu D, O'Neill KE, Manley NR, C Blackburn C
JournalRegen Med
Volume10
Issue3
Pagination317-29
Date Published2015 May
ISSN1746-076X
Abstract

The thymus is required for generation of a self-tolerant, self-restricted T-cell repertoire. The capacity to manipulate or replace thymus function therapeutically would be beneficial in a variety of clinical settings, including for improving recovery following bone marrow transplantation, restoring immune system function in the elderly and promoting tolerance to transplanted organs or cells. An attractive strategy would be transplantation of thymus organoids generated from cells produced in vitro, for instance from pluripotent stem cells. Here, we review recent progress toward this goal, focusing on advances in directing differentiation of pluripotent stem cells to thymic epithelial cells, a key cell type of the thymic stroma, and related direct reprogramming strategies.

DOI10.2217/rme.15.8
Alternate JournalRegen Med
PubMed ID25933240
Publication institute
CRM