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Adrenal-specific transgene expression and derivation of conditionally immortal rat adrenocortical cell lines.

TitleAdrenal-specific transgene expression and derivation of conditionally immortal rat adrenocortical cell lines.
Publication TypeJournal Article
Year of Publication1995
AuthorsMorley SD, Viard I, Parker KL, Mullins JJ
JournalEndocr Res
Volume21
Issue1-2
Pagination353-7
Date Published1995 Feb-May
ISSN0743-5800
KeywordsAdrenal Cortex, Animals, Animals, Genetically Modified, Antigens, Viral, Cell Differentiation, Cell Line, Cell Survival, Gene Expression, Mice, Mice, Transgenic, Organ Specificity, Phenotype, Rats, Rats, Inbred F344, Simian virus 40, Temperature
Abstract

Conditional immortalisation of cells is a powerful tool for establishing in vitro models maintaining a differentiated phenotype. We are utilising this approach to derive cell lines that maintain the characteristics of glomerulosa and fasciculata cells of the adrenal cortex. Such cell lines should provide a system in which to study aspects of adrenocortical function that are relevant to hypertension, such as the effects of the renin-angiotensin system on steroidogenesis.

Alternate JournalEndocr. Res.
PubMed ID7588398
Grant ListHL48460 / HL / NHLBI NIH HHS / United States