Val Wilson

Position:

Professor of Early Embryo Development

Telephone:

0131 651 9500

Biography:

Val studied for her PhD in Dr Martin Evans' lab in Cambridge from 1987-1991 on ES cell genetic manipulation and transgenesis. She then joined Rosa Beddington's lab to work on postimplantation mouse embryos, first in the Centre for Genome Research, Edinburgh from 1991-1992 and then in the National Institute for Medical Research from 1992-1996, Mill Hill, London. During this time she investigated the role of T(brachyury) in mouse anteroposterior axial elongation, using chimeras created by combining mutant ES cell lines and wild type blastocysts. She moved to Edinburgh in 1996 to set up her own lab to try and understand more fully the mechanisms of axis elongation, first as an MRC Career Development Fellow in the Molecular Medicine Centre, then at the Institute for Stem Cell Research, and most recently in the MRC Centre for Regenerative Medicine, after obtaining a university position.

Publications

2018

Human axial progenitors generate trunk neural crest cells in vitro. Frith, Jr, Thomas, Granata Ilaria, Wind Matthew, Stout Erin, Thompson Oliver, Neumann Katrin, Stavish Dylan, Heath Paul R., Ortmann Daniel, Hackland James Os, et al. , Elife, 2018 Aug 10, Volume 7, (2018)

BMP and FGF signaling interact to pattern mesoderm by controlling basic helix-loop-helix transcription factor activity. Row, Richard H., Pegg Amy, Kinney Brian A., Farr Gist H., Maves Lisa, Lowell Sally, Wilson Valerie, and Martin Benjamin L. , Elife, 2018 Jun 07, Volume 7, (2018)

A human iPSC line capable of differentiating into functional macrophages expressing ZsGreen: a tool for the study and tracking of therapeutic cells. Lopez-Yrigoyen, Martha, Fidanza Antonella, Cassetta Luca, Axton Richard A., A Taylor Helen, Meseguer-Ripolles Jose, Tsakiridis Anestis, Wilson Valerie, Hay David C., Pollard Jeffrey W., et al. , Philos Trans R Soc Lond B Biol Sci, 2018 Jul 05, Volume 373, Issue 1750, (2018)

Mapping transcription factor occupancy using minimal numbers of cells in vitro and in vivo. Tosti, Luca, Ashmore James, Tan Boon Siang Nich, Carbone Benedetta, Mistri Tapan K., Wilson Valerie, Tomlinson Simon R., and Kaji Keisuke , Genome Res, 2018 Apr, Volume 28, Issue 4, p.592-605, (2018)

2017

Distinct SoxB1 networks are required for naïve and primed pluripotency. Corsinotti, Andrea, Wong Frederick Ck, Tatar Tülin, Szczerbinska Iwona, Halbritter Florian, Colby Douglas, Gogolok Sabine, Pantier Raphaël, Liggat Kirsten, Mirfazeli Elham S., et al. , Elife, 2017 12 19, Volume 6, (2017)

A Gene Regulatory Network Balances Neural and Mesoderm Specification during Vertebrate Trunk Development. Gouti, Mina, Delile Julien, Stamataki Despina, Wymeersch Filip J., Huang Yali, Kleinjung Jens, Wilson Valerie, and Briscoe James , Dev Cell, 2017 May 08, Volume 41, Issue 3, p.243-261.e7, (2017)

2016

Development of Early Embryonic Lineages. In Kaufman’s Atlas of Mouse Development Supplement. pp. 65–76. Elsevier Lawson, K A., and Wilson Valerie , (2016)

A Revised Staging of Mouse Development Before Organogenesis. In Kaufman’s Atlas of Mouse Development Supplement. pp. 51–64. Elsevier Lawson, K A., and Wilson Valerie , (2016)

Somatic activating mutations in Pik3ca cause sporadic venous malformations in mice and humans Castillo, S. D., Tzouanacou E., Zaw-Thin M., Berenjeno I. M., Parker V. E. R., Chivite I., Mila-Guasch M., Pearce W., Solomon I., Angulo-Urarte A., et al. , Science Translational Medicine, Jun-03-2018, Volume 8, Issue 332, p.332ra43 - 332ra43, (2016)

Position-dependent plasticity of distinct progenitor types in the primitive streak. Wymeersch, Filip J., Huang Yali, Blin Guillaume, Cambray Noemí, Wilkie Ron, Wong Frederick Ck, and Wilson Valerie , Elife, 2016, Volume 5, (2016)

2015

Methods for Precisely Localized Transfer of Cells or DNA into Early Postimplantation Mouse Embryos. Huang, Yali, Wilkie Ron, and Wilson Valerie , J Vis Exp, 2015, Issue 106, (2015)

Assessing the bipotency of in vitro-derived neuromesodermal progenitors. Tsakiridis, Anestis, and Wilson Valerie , F1000Res, 2015, Volume 4, p.100, (2015)

Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation. Economou, Constantinos, Tsakiridis Anestis, Wymeersch Filip J., Gordon-Keylock Sabrina, Dewhurst Robert E., Fisher Dawn, Medvinsky A L., Smith A G., and Wilson Valerie , BMC Dev Biol, 2015, Volume 15, Issue 1, p.35, (2015)

2014

In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity. Gouti, Mina, Tsakiridis Anestis, Wymeersch Filip J., Huang Yali, Kleinjung Jens, Wilson Valerie, and Briscoe James , PLoS Biol, 2014 Aug, Volume 12, Issue 8, p.e1001937, (2014)

Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors. Tsakiridis, Anestis, Huang Yali, Blin Guillaume, Skylaki Stavroula, Wymeersch Filip J., Osorno Rodrigo, Economou Constantinos, Karagianni Eleni, Zhao Suling, Lowell Sally, et al. , Development, 2014 Mar, Volume 141, Issue 6, p.1209-21, (2014)

2013

Sequential effects of spadetail, one-eyed pinhead and no tail on midline convergence of nephric primordia during zebrafish embryogenesis. Huang, Chiu-Ju, Wilson Valerie, Pennings Sari, MacRae Calum A., and Mullins John J. , Dev Biol, 2013 Dec 15, Volume 384, Issue 2, p.290-300, (2013)

The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states. Festuccia, Nicola, Osorno Rodrigo, Wilson Valerie, and Chambers Ian , Curr Opin Genet Dev, 2013 Oct, Volume 23, Issue 5, p.504-11, (2013)

2012

In Vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation. Huang, Yali, Osorno Rodrigo, Tsakiridis Anestis, and Wilson Valerie , Cell Rep, 2012 Dec 27, Volume 2, Issue 6, p.1571-8, (2012)

The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression. Osorno, Rodrigo, Tsakiridis Anestis, Wong Frederick, Cambray Noemí, Economou Constantinos, Wilkie Ron, Blin Guillaume, Scotting Paul J., Chambers Ian, and Wilson Valerie , Development, 2012 Jul, Volume 139, Issue 13, p.2288-98, (2012)

2011

Creation of human-animal entities for translational stem cell research: Scientific explanation of issues that are often confused Lindvall, Olle, Kokaia Zaal, and Wilson Valerie , Translational Stem Cell Research: Issues Beyond the Debate on the Moral Status of the Human Embryo, Totowa, NJ, p.3 - 14, (2011)

2010

Cdx mutant axial progenitor cells are rescued by grafting to a wild type environment. Bialecka, Monika, Wilson Valerie, and Deschamps Jacqueline , Dev Biol, 2010 Nov 1, Volume 347, Issue 1, p.228-34, (2010)

2009

Redefining the progression of lineage segregations during mammalian embryogenesis by clonal analysis. Tzouanacou, Elena, Wegener Amélie, Wymeersch Filip J., Wilson Valerie, and Nicolas Jean-François , Dev Cell, 2009 Sep, Volume 17, Issue 3, p.365-76, (2009)

Stem cells, signals and vertebrate body axis extension. Wilson, Valerie, Olivera-Martinez Isabel, and Storey Kate G. , Development, 2009 May, Volume 136, Issue 10, p.1591-604, (2009)

Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Tsakiridis, Anestis, Tzouanacou Elena, Rahman Afifah, Colby Douglas, Axton Richard A., Chambers Ian, Wilson Valerie, Forrester Lesley M., and Brickman Joshua M. , Nucleic Acids Res, 2009 Oct, Volume 37, Issue 19, p.e129, (2009)

2008

Localised axial progenitor cell populations in the avian tail bud are not committed to a posterior Hox identity. McGrew, Michael J., Sherman Adrian, Lillico Simon G., Ellard Fiona M., Radcliffe Pippa A., Gilhooley Hazel J., Mitrophanous Kyriacos A., Cambray Noemí, Wilson Valerie, and Sang Helen M. , Development, 2008 Jul, Volume 135, Issue 13, p.2289-99, (2008)

2007

Two distinct sources for a population of maturing axial progenitors. Cambray, Noemí, and Wilson Valerie , Development, 2007 Aug, Volume 134, Issue 15, p.2829-40, (2007)

Essential alterations of heparan sulfate during the differentiation of embryonic stem cells to Sox1-enhanced green fluorescent protein-expressing neural progenitor cells. Johnson, Claire E., Crawford Brett E., Stavridis Marios, Dam Gerdy Ten, Wat Annie L., Rushton Graham, Ward Christopher M., Wilson Valerie, van Kuppevelt Toin H., Esko Jeffrey D., et al. , Stem Cells, 2007 Aug, Volume 25, Issue 8, p.1913-23, (2007)

A novel triple fusion reporter system for use in gene trap mutagenesis. Tsakiridis, Anestis, Tzouanacou Elena, Larralde Osmany, Watts Tim M., Wilson Valerie, Forrester Lesley M., and Brickman Joshua M. , Genesis, 2007 Jun, Volume 45, Issue 6, p.353-60, (2007)

2006

The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Kaji, Keisuke, Caballero Isabel Martín, MacLeod Ruth, Nichols Jennifer, Wilson Valerie, and Hendrich Brian , Nat Cell Biol, 2006 Mar, Volume 8, Issue 3, p.285-92, (2006)

2005

In vivo and in vitro assays of thymic organogenesis. Gordon, Julie, Wilson Valerie, Moore-Scott Billie A., Manley Nancy R., and C Blackburn Clare , Methods Mol Med, 2005, Volume 105, p.303-10, (2005)

2004

Functional evidence for a single endodermal origin for the thymic epithelium. Gordon, Julie, Wilson Valerie, Blair Natalie F., Sheridan Julie M., Farley Alison, Wilson Linda, Manley Nancy R., and C Blackburn Clare , Nat Immunol, 2004 May, Volume 5, Issue 5, p.546-53, (2004)

2003

Identification of Jade1, a gene encoding a PHD zinc finger protein, in a gene trap mutagenesis screen for genes involved in anteroposterior axis development. Tzouanacou, Elena, Tweedie Susan, and Wilson Valerie , Mol Cell Biol, 2003 Dec, Volume 23, Issue 23, p.8553-2, (2003)

Specific modification of heparan sulphate is required for normal cerebral cortical development. McLaughlin, David, Karlsson Fredrik, Tian Natasha, Pratt Tom, Bullock Simon L., Wilson Valerie, Price D J., and Mason J O. , Mech Dev, 2003 Dec, Volume 120, Issue 12, p.1481-8, (2003)

2002

Visualization of whole-mount skeletal expression patterns of LacZ reporters using a tissue clearing protocol. Kawaguchi, Jitsutaro, Wilson Valerie, and Mee P J. , Biotechniques, 2002 Jan, Volume 32, Issue 1, p.66, 68-70, 72-3, (2002)

Growth and early postimplantation defects in mice deficient for the bromodomain-containing protein Brd4. Houzelstein, Denis, Bullock Simon L., Lynch Denise E., Grigorieva Elena F., Wilson Valerie, and Beddington R S. , Mol Cell Biol, 2002 Jun, Volume 22, Issue 11, p.3794-802, (2002)

Role of heparan sulfate-2-O-sulfotransferase in the mouse. Merry, Catherine L. R., and Wilson Valerie , Biochim Biophys Acta, 2002 Dec 19, Volume 1573, Issue 3, p.319-27, (2002)

2001

Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. Hendrich, Brian, Guy J, Ramsahoye B, Wilson Valerie, and Bird A , Genes Dev, 2001 Mar 15, Volume 15, Issue 6, p.710-23, (2001)

2000

Eomesodermin is required for mouse trophoblast development and mesoderm formation. Russ, A P., Wattler S, Colledge W H., Aparicio S A., Carlton M B., Pearce J J., Barton S C., Surani M A., Ryan K, Nehls M C., et al. , Nature, 2000 Mar 2, Volume 404, Issue 6773, p.95-9, (2000)

1995

The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation. Wilson, Valerie, Manson L, Skarnes W C., and Beddington R S. , Development, 1995 Mar, Volume 121, Issue 3, p.877-86, (1995)

1992

Brachyury--a gene affecting mouse gastrulation and early organogenesis. Beddington, R S., Rashbass P, and Wilson Valerie , Dev Suppl, 1992, p.157-65, (1992)

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