Stuart Forbes

Position:

Director CRM, Professor of Transplantation and Regenerative Medicine; Consultant Hepatologist Scottish Liver Transplant Unit

Telephone:

0131 651 9510 (PA)

Display email:

IRR-Director@ed.ac.uk

Biography:

Director MRC Centre for Regenerative Medicine
Director UKRMP The Engineered Cell Environment Hub
Professor of Transplantation and Regenerative Medicine
Consultant Hepatologist Scottish Liver Transplant Unit

Publications

2019

Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration. Aloia, Luigi, McKie Mikel Alexander, Vernaz Grégoire, Cordero-Espinoza Lucía, Aleksieva Niya, van den Ameele Jelle, Antonica Francesco, Font-Cunill Berta, Raven Alexander, Cigliano Riccardo Aiese, et al. , Nat Cell Biol, 2019 Nov, Volume 21, Issue 11, p.1321-1333, (2019)

2018

Hepatocyte-specific β-catenin deletion during severe liver injury provokes cholangiocytes to differentiate into hepatocytes. Russell, Jacquelyn O., Lu Wei-Yu, Okabe Hirohisa, Abrams Marc, Oertel Michael, Poddar Minakshi, Singh Sucha, Forbes Stuart J., and Monga Satdarshan P. , Hepatology, 2018 Sep 14, (2018)

3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo. Rashidi, Hassan, Luu Nguyet-Thin, Alwahsh Salamah M., Ginai Maaria, Alhaque Sharmin, Dong Hua, Tomaz Rute A., Vernay Bertrand, Vigneswara Vasanthy, Hallett John M., et al. , Arch Toxicol, 2018 Oct, Volume 92, Issue 10, p.3117-3129, (2018)

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Bird, Thomas G., Müller Miryam, Boulter Luke, Vincent David F., Ridgway Rachel A., Lopez-Guadamillas Elena, Lu Wei-Yu, Jamieson Thomas, Govaere Olivier, Campbell Andrew D., et al. , Sci Transl Med, 2018 Aug 15, Volume 10, Issue 454, (2018)

The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury. Campana, Lara, Lewis Philip J. Starkey, Pellicoro Antonella, Aucott Rebecca L., Man Janet, O'Duibhir Eoghan, Mok Sarah E., Ferreira-González Sofía, Livingstone Eilidh, Greenhalgh Stephen N., et al. , J Immunol, 2018 Feb 01, Volume 200, Issue 3, p.1169-1187, (2018)

Paracrine cellular senescence exacerbates biliary injury and impairs regeneration. Ferreira-González, Sofía, Lu Wei-Yu, Raven Alexander, Dwyer Benjamin, Man Tak Yung, O'Duibhir Eoghan, Lewis Philip J. Starkey, Campana Lara, Kendall Tim J., Bird Thomas G., et al. , Nat Commun, 2018 Mar 09, Volume 9, Issue 1, p.1020, (2018)

2017

Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury. Haideri, Sharmin S., McKinnon Alison C., A Taylor Helen, Kirkwood Phoebe, Lewis Philip J. Starkey, O'Duibhir Eoghan, Vernay Bertrand, Forbes Stuart J., and Forrester Lesley M. , NPJ Regen Med, 2017, Volume 2, p.14, (2017)

Development, functional characterization and validation of methodology for GMP-compliant manufacture of phagocytic macrophages: A novel cellular therapeutic for liver cirrhosis. Fraser, Alasdair R., Pass Chloe, Burgoyne Paul, Atkinson Anne, Bailey Laura, Laurie Audrey, McGowan Neil W. A., Hamid Akib, Moore Joanna K., Dwyer Benjamin J., et al. , Cytotherapy, 2017 Jun 30, (2017)

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration. Raven, Alexander, Lu Wei-Yu, Man Tak Yung, Ferreira-González Sofía, O'Duibhir Eoghan, Dwyer Benjamin J., Thomson John P., Meehan Richard R., Bogorad Roman, Koteliansky Victor, et al. , Nature, 2017 Jul 12, (2017)

Injection of embryonic stem cell derived macrophages ameliorates fibrosis in a murine model of liver injury Haideri, Sharmin S., McKinnon Alison C., A. Taylor Helen, Kirkwood Phoebe, Lewis Philip J. Starkey, O'Duibhir Eoghan, Vernay Bertrand, Forbes Stuart J., and Forrester Lesley M. , npj Regenerative Medicine, Jan-12-2017, Volume 2201345340533010911011514617385458833621119117633130, Issue 1, (2017)

Milk Fat Globule-EGF Factor 8 for Liver Fibrosis Therapy: Creaming Off the Beneficial Effects of Mesenchymal Stromal Cells. Forbes, Stuart J. , Gastroenterology, 2017 Mar 01, (2017)

Patients with the worst outcomes after paracetamol (acetaminophen)-induced liver failure have an early monocytopenia. Moore, J K., Mackinnon A C., Man T Y., Manning J R., Forbes Stuart J., and Simpson K J. , Aliment Pharmacol Ther, 2017 Feb, Volume 45, Issue 3, p.443-454, (2017)

Functionalized superparamagnetic iron oxide nanoparticles provide highly efficient iron-labeling in macrophages for magnetic resonance-based detection in vivo. Sharkey, Jack, Lewis Philip J. Starkey, Barrow Michael, Alwahsh Salamah M., Noble June, Livingstone Eilidh, Lennen Ross J., Jansen Maurits A., Carrion Jaime Garcia, Liptrott Neill, et al. , Cytotherapy, 2017 Feb 15, (2017)

2016

Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference. Abou-Alfa, Ghassan K., Andersen Jesper B., Chapman William, Choti Michael, Forbes Stuart J., Gores Gregory J., Hong Theodore S., Harding James J., Heiden Matthew G. Vander, Javle Milind, et al. , J Gastrointest Oncol, 2016 Dec, Volume 7, Issue 6, p.819-827, (2016)

Liver regeneration - mechanisms and models to clinical application. Forbes, Stuart J., and Newsome Philip N. , Nat Rev Gastroenterol Hepatol, 2016 Aug, Volume 13, Issue 8, p.473-85, (2016)

Interleukin-13 Activates Distinct Cellular Pathways Leading to Ductular Reaction, Steatosis, and Fibrosis. Gieseck, Richard L., Ramalingam Thirumalai R., Hart Kevin M., Vannella Kevin M., Cantu David A., Lu Wei-Yu, Ferreira-González Sofía, Forbes Stuart J., Vallier Ludovic, and Wynn Thomas A. , Immunity, 2016 Jul 19, Volume 45, Issue 1, p.145-58, (2016)

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers. Carotenuto, Pietro, Fassan Matteo, Pandolfo Rosantony, Lampis Andrea, Vicentini Caterina, Cascione Luciano, Paulus-Hock Viola, Boulter Luke, Guest Rachel, Quagliata Luca, et al. , Gut, 2016 Sep 12, (2016)

Notch3 drives development and progression of cholangiocarcinoma. Guest, Rachel V., Boulter Luke, Dwyer Benjamin J., Kendall Timothy J., Man Tak-Yung, Minnis-Lyons Sarah E., Lu Wei-Yu, Robson Andrew J., Gonzalez Sofia Ferreira, Raven Alexander, et al. , Proc Natl Acad Sci U S A, 2016 Oct 25, Volume 113, Issue 43, p.12250-12255, (2016)

Corrigendum to "Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma" [J Hepatol 2015;62:607-616]. Yeung, Oscar W. H., Lo Chung-Mau, Ling Chang-Chun, Qi Xiang, Geng Wei, Li Chang-Xian, Ng Kevin T. P., Forbes Stuart J., Guan Xin-Yuan, Poon Ronnie T. P., et al. , J Hepatol, 2016 Jun, Volume 64, Issue 6, p.1461, (2016)

Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA). Banales, Jesus M., Cardinale Vincenzo, Carpino Guido, Marzioni Marco, Andersen Jesper B., Invernizzi Pietro, Lind Guro E., Folseraas Trine, Forbes Stuart J., Fouassier Laura, et al. , Nat Rev Gastroenterol Hepatol, 2016 May, Volume 13, Issue 5, p.261-80, (2016)

The RSPO-LGR4/5-ZNRF3/RNF43 module controls liver zonation and size. Planas-Paz, Lara, Orsini Vanessa, Boulter Luke, Calabrese Diego, Pikiolek Monika, Nigsch Florian, Xie Yang, Roma Guglielmo, Donovan Adriana, Marti Patricia, et al. , Nat Cell Biol, 2016 May, Volume 18, Issue 5, p.467-79, (2016)

Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs. Szkolnicka, Dagmara, Lucendo-Villarin Baltasar, Moore Joanna K., Simpson Kenneth J., Forbes Stuart J., and Hay David C. , Stem Cells Transl Med, 2016 Apr 7, (2016)

Vasopressin Regulates Extracellular Vesicle Uptake by Kidney Collecting Duct Cells. Oosthuyzen, Wilna, Scullion Kathleen M., Ivy Jessica R., Morrison Emma E., Hunter Robert W., Lewis Philip J. Starkey, O'Duibhir Eoghan, Street Jonathan M., Caporali Andrea, Gregory Christopher D., et al. , J Am Soc Nephrol, 2016 Mar 28, (2016)

2015

Recombinant Laminins Drive the Differentiation and Self-Organization of hESC-Derived Hepatocytes. Cameron, Kate, Tan Rosanne, Schmidt-Heck Wolfgang, Campos Gisela, Lyall Marcus J., Wang Yu, Lucendo-Villarin Baltasar, Szkolnicka Dagmara, Bates Nicola, Kimber Susan J., et al. , Stem Cell Reports, 2015 Dec 8, Volume 5, Issue 6, p.1250-62, (2015)

Galectin-3 regulates hepatic progenitor cell expansion during liver injury Hsieh, W.-C., Mackinnon A. C., Lu W.-Y., Jung J., Boulter L., Henderson N. C., Simpson K. J., Schotanus B., Wojtacha D., Bird T. G., et al. , Gut, Jan-02-2015, Volume 64, Issue 2, p.312 - 321, (2015)

REpeated AutoLogous Infusions of STem cells In Cirrhosis (REALISTIC): a multicentre, phase II, open-label, randomised controlled trial of repeated autologous infusions of granulocyte colony-stimulating factor (GCSF) mobilised CD133+ King, A., Barton D., Beard H. A., Than N., Moore J., Corbett C., Thomas J., Guo K., Guha I., Hollyman D., et al. , BMJ Open, Jan-03-2015, Volume 5, Issue 3, p.e007700 - e007700, (2015)

Organoid cultures boost human liver cell expansion Forbes, Stuart J. , Hepatology, Jan-11-2015, Volume 62, Issue 5, p.1635 - 1637, (2015)

Krüppel-Like Factor 4 Overexpression Initiates a Mesenchymal-to-Epithelial Transition and Redifferentiation of Human Pancreatic Cells following Expansion in Long Term Adherent Culture. Muir, Kenneth R., Lima Maria João, Docherty Hilary M., Mcgowan Neil W. A., Forbes Shareen, Heremans Yves, Forbes Stuart J., Heimberg Harry, Casey John, and Docherty Kevin , PLoS One, 2015, Volume 10, Issue 10, p.e0140352, (2015)

Phenotypic and functional characterization of macrophages with therapeutic potential generated from human cirrhotic monocytes in a cohort study. Moore, Joanna K., Mackinnon Alison C., Wojtacha Davina, Pope Caroline, Fraser Alasdair R., Burgoyne Paul, Bailey Laura, Pass Chloe, Atkinson Anne, Mcgowan Neil W. A., et al. , Cytotherapy, 2015 Sep 2, (2015)

CSF1 Restores Innate Immunity Following Liver Injury in Mice and Serum Levels Indicate Outcomes of Patients With Acute Liver Failure. Stutchfield, Benjamin M., Antoine D J., Mackinnon A C., Gow D J., Bain C C., Hawley C A., Hughes M, Francis B, Wojtacha Davina, Man T Y., et al. , Gastroenterology, 2015 Sep 4, (2015)

Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015). Villarin, Baltasar Lucendo, Cameron Kate, Szkolnicka Dagmara, Rashidi H., Bates Nicola, Kimber Susan J., Flint Oliver, Forbes Stuart J., Iredale John P., Bradley Mark, et al. , Adv Healthc Mater, 2015 Aug, Volume 4, Issue 12, p.1819, (2015)

Hepatic progenitor cells of biliary origin with liver repopulation capacity. Lu, Wei-Yu, Bird Thomas G., Boulter Luke, Tsuchiya Atsunori, Cole Alicia M., Hay Trevor, Guest Rachel V., Wojtacha Davina, Man Tak Yung, Mackinnon Alison, et al. , Nat Cell Biol, 2015 Jul 20, (2015)

Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance. Lucendo-Villarin, Baltasar, Cameron Kate, Szkolnicka Dagmara, Rashidi H., Bates Nicola, Kimber Susan J., Flint Oliver, Forbes Stuart J., Iredale John P., Bradley Mark, et al. , Adv Healthc Mater, 2015 Jun 24, (2015)

Cell therapy for liver disease: From liver transplantation to cell factory. Forbes, Stuart J., Gupta Sanjeev, and Dhawan Anil , J Hepatol, 2015 Apr, Volume 62, Issue 1S, p.S157-S169, (2015)

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited. Boulter, Luke, Guest Rachel V., Kendall Timothy J., Wilson David H., Wojtacha Davina, Robson Andrew J., Ridgway Rachel A., Samuel Kay, van Rooijen Nico, Barry Simon T., et al. , J Clin Invest, 2015 Feb 17, (2015)

2014

Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma. Yeung, Oscar W. H., Lo Chung-Mau, Ling Chang-Chun, Qi Xiang, Geng Wei, Li Chang-Xian, Ng Kevin T. P., Forbes Stuart J., Guan Xin-Yuan, Poon Ronnie T. P., et al. , J Hepatol, 2014 Oct 30, (2014)

Preparing the ground for tissue regeneration: from mechanism to therapy. Forbes, Stuart J., and Rosenthal Nadia , Nat Med, 2014 Aug, Volume 20, Issue 8, p.857-69, (2014)

Regenerative medicine. Knocking on the door to successful hepatocyte transplantation. Forbes, Stuart J., and Alison Malcolm R. , Nat Rev Gastroenterol Hepatol, 2014 May, Volume 11, Issue 5, p.277-8, (2014)

Markedly Increased High-Mobility Group Box 1 Protein in a Patient with Small-for-Size Syndrome. Craig, Darren G., Lee Patricia, E Pryde Anne, Hidalgo Ernest, Hayes Peter C., Wigmore Stephen J., Forbes Stuart J., and Simpson Kenneth J. , Case Rep Transplant, 2014, Volume 2014, p.272498, (2014)

Systematic review: the effects of autologous stem cell therapy for patients with liver disease. Moore, J K., Stutchfield Benjamin M., and Forbes Stuart J. , Aliment Pharmacol Ther, 2014 Apr, Volume 39, Issue 7, p.673-85, (2014)

Recent advances in stem cells and regenerative medicine. Forbes, Stuart J. , QJM, 2014 Apr, Volume 107, Issue 4, p.251-2, (2014)

Proteinase activated receptor 1 mediated fibrosis in a mouse model of liver injury: a role for bone marrow derived macrophages. Kallis, Yiannis N., Scotton Christopher J., Mackinnon Alison C., Goldin Robert D., Wright Nicholas A., Iredale John P., Chambers Rachel C., and Forbes Stuart J. , PLoS One, 2014, Volume 9, Issue 1, p.e86241, (2014)

CD133+ cancer stem-like cells in small cell lung cancer are highly tumorigenic and chemoresistant but sensitive to a novel neuropeptide antagonist. Sarvi, Sana, Mackinnon Alison C., Avlonitis Nicolaos, Bradley Mark, Rintoul Robert C., Rassl Doris M., Wang Wei, Forbes Stuart J., Gregory Christopher D., and Sethi Tariq , Cancer Res, 2014 Mar 1, Volume 74, Issue 5, p.1554-65, (2014)

Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo. Fallowfield, Jonathan A., Hayden Annette L., Snowdon Victoria K., Aucott Rebecca L., Stutchfield Benjamin M., Mole Damian J., Pellicoro Antonella, Gordon-Walker Timothy T., Henke Alexander, Schrader Joerg, et al. , Hepatology, 2014 Apr, Volume 59, Issue 4, p.1492-504, (2014)

HGF and SDF-1-mediated mobilization of CD133+ BMSC for hepatic regeneration following extensive liver resection. Lehwald, Nadja, Duhme Constanze, Wildner Marina, Kuhn Stephanie, Fürst Günter, Forbes Stuart J., Jonas Sven, Robson Simon C., Knoefel Wolfram T., Schmelzle Moritz, et al. , Liver Int, 2014 Jan, Volume 34, Issue 1, p.89-101, (2014)

PolySia-NCAM modulates the formation of ductular reactions in liver injury. Tsuchiya, Atsunori, Lu Wei-Yu, Weinhold Birgit, Boulter Luke, Stutchfield Benjamin M., Williams Michael J., Guest Rachel V., Minnis-Lyons Sarah E., Mackinnon Alison C., Schwarzer David, et al. , Hepatology, 2014 Feb 28, (2014)

Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma. Guest, Rachel V., Boulter Luke, Kendall Timothy J., Minnis-Lyons Sarah E., Walker Robert, Wigmore Stephen J., Sansom Owen J., and Forbes Stuart J. , Cancer Res, 2014 Feb 15, Volume 74, Issue 4, p.1005-10, (2014)

Links between hepatic fibrosis, ductular reaction, and progenitor cell expansion. Williams, Michael J., Clouston Andrew D., and Forbes Stuart J. , Gastroenterology, 2014 Feb, Volume 146, Issue 2, p.349-56, (2014)

Galectin-3 regulates hepatic progenitor cell expansion during liver injury. Hsieh, Wei-Chen, Mackinnon Alison C., Lu Wei-Yu, Jung Jonathan, Boulter Luke, Henderson Neil C., Simpson Kenneth J., Schotanus Baukje, Wojtacha Davina, Bird Tom G., et al. , Gut, 2014 May 16, (2014)

2013

Differentiation of progenitors in the liver: a matter of local choice. Boulter, Luke, Lu Wei-Yu, and Forbes Stuart J. , J Clin Invest, 2013 May 1, Volume 123, Issue 5, p.1867-73, (2013)

Bone marrow contributions to fibrosis. Mackinnon, Alison C., and Forbes Stuart J. , Biochim Biophys Acta, 2013 Jul, Volume 1832, Issue 7, p.955-61, (2013)

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Bird, Tom G., Lu Wei-Yu, Boulter Luke, Gordon-Keylock Sabrina, Ridgway Rachel A., Williams Michael J., Taube Jessica, Thomas James A., Wojtacha Davina, Gambardella Adriana, et al. , Proc Natl Acad Sci U S A, 2013 Apr 16, Volume 110, Issue 16, p.6542-7, (2013)

Liver sinusoidal endothelial cells in disease--and for therapy? Stutchfield, Benjamin M., and Forbes Stuart J. , J Hepatol, 2013 Jan, Volume 58, Issue 1, p.178-80, (2013)

2012

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. Ramachandran, Prakash, Pellicoro Antonella, Vernon Madeleine A., Boulter Luke, Aucott Rebecca L., Ali Aysha, Hartland Stephen N., Snowdon Victoria K., Cappon Andrea, Gordon-Walker Timothy T., et al. , Proc Natl Acad Sci U S A, 2012 Nov 13, Volume 109, Issue 46, p.E3186-95, (2012)

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis. Pellicoro, Antonella, Aucott Rebecca L., Ramachandran Prakash, Robson Andrew J., Fallowfield Jonathan A., Snowdon Victoria K., Hartland Stephen N., Vernon Madeleine, Duffield Jeremy S., R Benyon Christopher, et al. , Hepatology, 2012 Jun, Volume 55, Issue 6, p.1965-75, (2012)

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Boulter, Luke, Govaere Olivier, Bird Tom G., Radulescu Sorina, Ramachandran Prakash, Pellicoro Antonella, Ridgway Rachel A., Seo Sang Soo, Spee Bart, van Rooijen Nico, et al. , Nat Med, 2012 Apr, Volume 18, Issue 4, p.572-9, (2012)

SUMOylation of HNF4α regulates protein stability and hepatocyte function. Zhou, Wenli, Hannoun Zara, Jaffray Ellis, Medine C. N., Black James R., Greenhough Sebastian, Zhu Liang, Ross James A., Forbes Stuart J., Wilmut Ian, et al. , J Cell Sci, 2012 Aug 1, Volume 125, Issue Pt 15, p.3630-5, (2012)

New horizons for stem cell therapy in liver disease. Forbes, Stuart J., and Newsome Philip N. , J Hepatol, 2012 Feb, Volume 56, Issue 2, p.496-9, (2012)

2011

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function. Thomas, James A., Pope Caroline, Wojtacha Davina, Robson Andrew J., Gordon-Walker Timothy T., Hartland Stephen N., Ramachandran Prakash, Van Deemter Marielle, Hume David A., Iredale John P., et al. , Hepatology, 2011 Jun, Volume 53, Issue 6, p.2003-15, (2011)

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Schrader, Jörg, Gordon-Walker Timothy T., Aucott Rebecca L., Van Deemter Marielle, Quaas Alexander, Walsh Shaun, Benten Daniel, Forbes Stuart J., Wells Rebecca G., and Iredale John P. , Hepatology, 2011 Apr, Volume 53, Issue 4, p.1192-205, (2011)

Liver fibrogenic cells. Forbes, Stuart J., and Parola Maurizio , Best Pract Res Clin Gastroenterol, 2011 Apr, Volume 25, Issue 2, p.207-17, (2011)

Ly6Chi monocytes direct alternatively activated profibrotic macrophage regulation of lung fibrosis. Gibbons, Michael A., Mackinnon Alison C., Ramachandran Prakash, Dhaliwal Kevin, Duffin Rodger, Phythian-Adams Alexander T., van Rooijen Nico, Haslett Christopher, Howie Sarah E., A Simpson John, et al. , Am J Respir Crit Care Med, 2011 Sep 1, Volume 184, Issue 5, p.569-81, (2011)

Unbiased screening of polymer libraries to define novel substrates for functional hepatocytes with inducible drug metabolism. Hay, David C., Pernagallo Salvatore, Diaz-Mochon Juan Jose, Medine C. N., Greenhough Sebastian, Hannoun Zara, Schrader Joerg, Black James R., Fletcher Judy, Dalgetty Donna, et al. , Stem Cell Res, 2011 Mar, Volume 6, Issue 2, p.92-102, (2011)

Remodelling of extracellular matrix is a requirement for the hepatic progenitor cell response. Kallis, Yiannis N., Robson Andrew J., Fallowfield Jonathan A., Thomas Howard C., Alison Malcolm R., Wright Nicholas A., Goldin Robert D., Iredale John P., and Forbes Stuart J. , Gut, 2011 Apr, Volume 60, Issue 4, p.525-33, (2011)

Persistence of functional hepatocyte-like cells in immune-compromised mice. Payne, Catherine, Samuel Kay, Pryde Anne, King Jason, Brownstein David, Schrader Joerg, Medine C. N., Forbes Stuart J., Iredale John P., Newsome Philip N., et al. , Liver Int, 2011 Feb, Volume 31, Issue 2, p.254-62, (2011)

2010

Prospects for stem cell transplantation in the treatment of hepatic disease. Stutchfield, Benjamin M., Forbes Stuart J., and Wigmore Stephen J. , Liver Transpl, 2010 Jul, Volume 16, Issue 7, p.827-36, (2010)

Liver development, regeneration, and carcinogenesis. Kung, Janet W. C., Currie Ian S., Forbes Stuart J., and Ross James A. , J Biomed Biotechnol, 2010, Volume 2010, p.984248, (2010)

Portal venous endothelium in developing human liver contains haematopoietic and epithelial progenitor cells. Terrace, John D., Hay David C., Samuel Kay, Anderson Richard A., Currie Ian S., Parks Rowan W., Forbes Stuart J., and Ross James A. , Exp Cell Res, 2010 May 15, Volume 316, Issue 9, p.1637-47, (2010)

Characterisation of a stereotypical cellular and extracellular adult liver progenitor cell niche in rodents and diseased human liver. Lorenzini, Stefania, Bird Tom G., Boulter Luke, Bellamy Christopher, Samuel Kay, Aucott Rebecca L., Clayton Elizabeth, Andreone Pietro, Bernardi Mauro, Golding Mathew, et al. , Gut, 2010 May, Volume 59, Issue 5, p.645-54, (2010)

Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Sullivan, Gareth, Hay David C., Park In-Hyun, Fletcher Judy, Hannoun Zara, Payne Catherine, Dalgetty Donna, Black James R., Ross James A., Samuel Kay, et al. , Hepatology, 2010 Jan, Volume 51, Issue 1, p.329-35, (2010)

Practical barriers to delivering autologous bone marrow stem cell therapy as an adjunct to liver resection. Stutchfield, Benjamin M., Rashid Sameena, Forbes Stuart J., and Wigmore Stephen J. , Stem Cells Dev, 2010 Feb, Volume 19, Issue 2, p.155-62, (2010)

2009

Stem cells and liver repair. Kung, Janet W. C., and Forbes Stuart J. , Curr Opin Biotechnol, 2009 Oct, Volume 20, Issue 5, p.568-74, (2009)

The bone marrow and liver fibrosis: friend or foe? Kallis, Yiannis N., and Forbes Stuart J. , Gastroenterology, 2009 Oct, Volume 137, Issue 4, p.1218-21, (2009)

Side population cells in developing human liver are primarily haematopoietic progenitor cells. Terrace, John D., Hay David C., Samuel Kay, Payne Catherine, Anderson Richard A., Currie Ian S., Parks Rowan W., Forbes Stuart J., and Ross James A. , Exp Cell Res, 2009 Aug 1, Volume 315, Issue 13, p.2141-53, (2009)

A fat chance for hepatocyte transplantation? Thomas, James A., and Forbes Stuart J. , Gut, 2009 Apr, Volume 58, Issue 4, p.480-2, (2009)

2008

Highly efficient differentiation of hESCs to functional hepatic endoderm requires ActivinA and Wnt3a signaling. Hay, David C., Fletcher Judy, Payne Catherine, Terrace John D., Gallagher Ronald C. J., Snoeys Jan, Black James R., Wojtacha Davina, Samuel Kay, Hannoun Zara, et al. , Proc Natl Acad Sci U S A, 2008 Aug 26, Volume 105, Issue 34, p.12301-6, (2008)

Hepatic fibrogenesis: from within and outwith. Henderson, Neil C., and Forbes Stuart J. , Toxicology, 2008 Dec 30, Volume 254, Issue 3, p.130-5, (2008)

Stem cell mobilization and collection in patients with liver cirrhosis. Lorenzini, S, Isidori A, Catani L, Gramenzi A, Talarico S, Bonifazi F, Giudice V, Conte R, Baccarani M, Bernardi M, et al. , Aliment Pharmacol Ther, 2008 May, Volume 27, Issue 10, p.932-9, (2008)

The inhibitory role of stromal cell mesenchyme on human embryonic stem cell hepatocyte differentiation is overcome by Wnt3a treatment. Fletcher, Judy, Cui Wei, Samuel Kay, Black James R., Hannoun Zara, Currie Ian S., Terrace John D., Payne Catherine, Filippi Celine, Newsome Philip N., et al. , Cloning Stem Cells, 2008 Sep, Volume 10, Issue 3, p.331-9, (2008)

Experimental hepatology applied to stem cells. Burra, P, Tomat S, Villa E, Gasbarrini A, Costa A N., Conconi M T., Forbes Stuart J., Farinati F, Cozzi E, Alison M R., et al. , Dig Liver Dis, 2008 Jan, Volume 40, Issue 1, p.54-61, (2008)

Activation of stem cells in hepatic diseases. Bird, Tom G., Lorenzini S, and Forbes Stuart J. , Cell Tissue Res, 2008 Jan, Volume 331, Issue 1, p.283-300, (2008)

Stem cell therapy for chronic liver disease--choosing the right tools for the job. Forbes, Stuart J. , Gut, 2008 Feb, Volume 57, Issue 2, p.153-5, (2008)

Regulation of alternative macrophage activation by galectin-3. Mackinnon, Alison C., Farnworth Sarah L., Hodkinson Philip S., Henderson Neil C., Atkinson Kirsten M., Leffler Hakon, Nilsson Ulf J., Haslett Christopher, Forbes Stuart J., and Sethi Tariq , J Immunol, 2008 Feb 15, Volume 180, Issue 4, p.2650-8, (2008)

2007

Progenitor cell characterization and location in the developing human liver. Terrace, John D., Currie Ian S., Hay David C., Masson Neil M., Anderson Richard A., Forbes Stuart J., Parks Rowan W., and Ross James A. , Stem Cells Dev, 2007 Oct, Volume 16, Issue 5, p.771-8, (2007)

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