Our main research interest is the development of label-free quantitative technologies to map biophysical properties (mechanical, optical, flow, electrical) of cells and tissues. They also address the need for real-time monitoring of 3D (spheroids, organoids) in vitro disease models, and the need to monitor tissue repair in pre-clinical studies. To this end, we currently investigate optical coherence tomography, impedance sensing and their combination into organ-on-a chip technologies with a focus on ophthalmological applications.
We currently have projects on:
- Optical coherence tomography for tissue engineering and regenerative medicine - Fourier-Domain optical coherence tomography - Optical coherence microscopy Noninvasive biosensors and quantitative methods in medicine and biology - Electric cell-substrate impedance sensing (ECIS, http://www.biophysics.com/)
- Common-path optical coherence phase microscopy – live cell optical fluctuations Pierre Bagnaninchi is a member of EPSRC, BBSRC and MRC funded Organ on a chip technologies network (www.organonachip.org.uk), for which he leads a Special interest group: Label-free real-time monitoring, translation to organ on a chip.
- Holmes C, Bagnaninchi J.,Daoud Tabrizian M, Polyelectrolyte multilayer coating of 3D scaffolds enhances tissue growth and gene delivery: Non-invasive and label-free assessment; Adv Healthc Mater. 2013 Sep 12. doi: 10.1002/adhm.201300301
- R. Mouras, P. Bagnaninchi, A. Downes, and A. Elfick “Multimodal, label-free nonlinear optical imaging for applications in biology and biomedical science”. J. Raman Spectrosc, (2013) first online
- Holmes C, Tabrizian M, Bagnaninchi P. Motility imaging via optical coherence phase microscopy enables label-free monitoring of tissue growth and viability in 3D tissue engineering scaffolds. J Tissue Eng Regen Med. 2013 Feb 12. doi: 10.1002/term.1687. [Epub ahead of print]
- Bagnaninchi, P. and N. Drummond, “Real-time label-free monitoring of adipose-derived stem cell differentiation with electric cell-substrate impedance sensing.,” Proceedings of the National Academy of Sciences, vol. 108, no. 16, pp. 6462–6467, Apr. 2011. http://www.pnas.org/content/early/2011/03/30/1018260108.full.pdf+html
- Bagnaninchi, P. Christina Holmes, Nicola Drummond, Jamal Daoud, and M. Tabrizian. Two-dimensional and three-dimensional viability measurements of adult stem cells with optical coherence phase microscopy. J. Biomed. Opt. 16, 086003 (2011)