Keisuke Kaji

Position:

Group Leader, Professor of Biology of Reprogramming and MRC Senior Non-Clinical Fellow

Telephone:

0131 651 9551

Display email:

keisuke.kaji@ed.ac.uk

Biography:

2016- MRC Senior Non-Clinical Fellow
2008- Group Leader, MRC Centre for Regenerative Medicine, University of Edinburgh
2003-2007 Postdoctral fellow in Dr. Brian Hendrich group at Institute for Stem Cell Research, The University of Edinburgh
2003 PhD. Department of Biological Information, Tokyo Institute of Technology
2000 MSc. Department of Life Science, Tokyo Institute of Technology
1998 BSc. Department of Life Science, Tokyo Institute of Technology

Publications

2018

Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic Reprogramming. Ward, Carl, Volpe Giacomo, Cauchy Pierre, Ptasinska Anetta, Almaghrabi Ruba, Blakemore Daniel, Nafria Monica, Kestner Doris, Frampton Jon, Murphy George, et al. , Cell Rep, 2018 Aug 07, Volume 24, Issue 6, p.1496-1511.e8, (2018)

Mapping transcription factor occupancy using minimal numbers of cells in vitro and in vivo. Tosti, Luca, Ashmore James, Tan Boon Siang Nich, Carbone Benedetta, Mistri Tapan K., Wilson Valerie, Tomlinson Simon R., and Kaji Keisuke , Genome Res, 2018 Apr, Volume 28, Issue 4, p.592-605, (2018)

2017

Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming. Ruetz, Tyson, Pfisterer Ulrich, Di Stefano Bruno, Ashmore James, Beniazza Meryam, Tian Tian V., Kaemena Daniel F., Tosti Luca, Tan Wenfang, Manning Jonathan R., et al. , Cell Stem Cell, 2017 Nov 13, (2017)

Coupling shRNA screens with single-cell RNA-seq identifies a dual role for mTOR in reprogramming-induced senescence. Aarts, Marieke, Georgilis Athena, Beniazza Meryam, Beolchi Patrizia, Banito Ana, Carroll Thomas, Kulisic Marizela, Kaemena Daniel F., Dharmalingam Gopuraja, Martin Nadine, et al. , Genes Dev, 2017 Oct 15, Volume 31, Issue 20, p.2085-2098, (2017)

2015

Acute Loss of Cited2 Impairs Nanog Expression and Decreases Self-Renewal of Mouse Embryonic Stem Cells Kranc, Kamil R., Oliveira Daniel V., Armesilla-Diaz Alejandro, Pacheco-Leyva Ivette, Matias Ana Catarina, Escapa Ana Luisa, Subramani Chithra, Wheadon Helen, Trindade Marlene, Nichols Jennifer, et al. , STEM CELLS, Jan-03-2015, Volume 33, Issue 3, p.699 - 712, (2015)

Reprogramming Roadblocks Are System Dependent. Chantzoura, Eleni, Skylaki Stavroula, Menendez Sergio, Kim Shin-Il, Johnsson Anna, Linnarsson Sten, Woltjen Knut, Chambers Ian, and Kaji Keisuke , Stem Cell Reports, 2015 Sep 8, Volume 5, Issue 3, p.350-64, (2015)

2014

Routes to induced pluripotent stem cells. Ruetz, Tyson, and Kaji Keisuke , Curr Opin Genet Dev, 2014 Sep 2, Volume 28C, p.38-42, (2014)

MBD3/NuRD Facilitates Induction of Pluripotency in a Context-Dependent Manner. Santos, Rodrigo L. Dos, Tosti Luca, Radzisheuskaya Aliaksandra, Caballero Isabel M., Kaji Keisuke, Hendrich Brian, and Silva Jose , Cell Stem Cell, 2014 Jul 3, Volume 15, Issue 1, p.102-10, (2014)

2013

ERK2 suppresses self-renewal capacity of embryonic stem cells, but is not required for multi-lineage commitment. Hamilton, William B., Kaji Keisuke, and Kunath Tilo , PLoS One, 2013, Volume 8, Issue 4, p.e60907, (2013)

High-resolution analysis with novel cell-surface markers identifies routes to iPS cells. O'Malley, James, Skylaki Stavroula, Iwabuchi Kumiko A., Chantzoura Eleni, Ruetz Tyson, Johnsson Anna, Tomlinson Simon R., Linnarsson Sten, and Kaji Keisuke , Nature, 2013 Jul 4, Volume 499, Issue 7456, p.88-91, (2013)

2012

Transcriptional activation by Oct4 is sufficient for the maintenance and induction of pluripotency. Hammachi, Fella, Morrison Gillian M., Sharov Alexei A., Livigni Alessandra, Narayan Santosh, Papapetrou Eirini P., O'Malley James, Kaji Keisuke, Ko Minoru S. H., Ptashne Mark, et al. , Cell Rep, 2012 Feb 23, Volume 1, Issue 2, p.99-109, (2012)

2009

New strategies to generate induced pluripotent stem cells. O'Malley, James, Woltjen Knut, and Kaji Keisuke , Curr Opin Biotechnol, 2009 Oct, Volume 20, Issue 5, p.516-21, (2009)

Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Kaji, Keisuke, Norrby Katherine, Paca Agnieszka, Mileikovsky Maria, Mohseni Paria, and Woltjen Knut , Nature, 2009 Apr 9, Volume 458, Issue 7239, p.771-5, (2009)

piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Woltjen, Knut, Michael Iacovos P., Mohseni Paria, Desai Ridham, Mileikovsky Maria, Hämäläinen Riikka, Cowling Rebecca, Wang Wei, Liu Pentao, Gertsenstein Marina, et al. , Nature, 2009 Apr 9, Volume 458, Issue 7239, p.766-70, (2009)

2007

Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Kaji, Keisuke, Nichols Jennifer, and Hendrich Brian , Development, 2007 Mar, Volume 134, Issue 6, p.1123-32, (2007)

2006

The NuRD component Mbd3 is required for pluripotency of embryonic stem cells. Kaji, Keisuke, Caballero Isabel Martín, MacLeod Ruth, Nichols Jennifer, Wilson Valerie, and Hendrich Brian , Nat Cell Biol, 2006 Mar, Volume 8, Issue 3, p.285-92, (2006)

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