Ian Chambers

Position:

Professor of Pluripotent Stem Cell Biology

Telephone:

0131 651 9500

Display email:

i.chambers@ed.ac.uk

Biography:

1983 - BSc (Honours, 1st Class): Biochemistry, Strathclyde, Glasgow
1987 - PhD: Beatson Institute for Cancer Research, Glasgow
1987 - 1991: Postdoc with Nobel Laureate Paul Berg, Stanford, USA
1991 - 2006: Senior Postdoc with Austin Smith, Edinburgh
2007 - 2010: Reader, Edinburgh
2010 - present: Professor of Pluripotent Stem Cell Biology, Edinburgh

Landmark achievements

Ian identified UGA, normally a ‘STOP’ codon, as encoding the 21st amino acid selenocysteine.

Ian is co-discoverer of Nanog, a pluripotent-specific transcription factor that can confer LIF-independent ES cell self-renewal. Ian therefore named Nanog after TirnanOg, the Celtic Land-of-the-Ever-Young. This work was cited as a “landmark achievement in UK research” in the UK Stem Cell Initiative Pattison Report.

Discovered heterogeneous transcription factor expression within the pluripotent cell compartment. Cells with lowered Nanog expression are primed for, but uncommitted to differentiation.

Identified Otx2 as a key regulator of germline/soma segregation. Notably, without an Otx2 gene, pluripotent cells can differentiate into the germline as a default mechanism.

Additional publications:

• Gagliardi A, Mullin NP, Ying Tan Z, Colby D, Kousa AI, Halbritter F, Weiss JT, Felker A, Bezstarosti K, Favaro R, Demmers J, Nicolis SK, Tomlinson SR, Poot RA, Chambers I. 2013. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J. 32(16):2231-47.
• Karwacki-Neisius V, Göke J, Osorno R, Halbritter F, Ng JH, Weiße AY, Wong FCK, Gagliardi A, Mullin NP, Festuccia N, Colby D, Tomlinson SR, Ng H-H and Chambers I. 2013. Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell 12:531-545. Press release.
• Navarro P, Festuccia N, Colby D, Gagliardi A, Mullin N, Zhang W, Karwacki-Neisius V, Osorno R, Kelly D, Robertson M and Chambers I. 2012. OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO Journal 31:4547-62.
• Festuccia N, Osorno R, Florian Halbritter F, Karwacki-Neisius V, Navarro P, Colby D, Wong F, Yates A, Tomlinson SR, Chambers I. 2012. Esrrb Is a Direct Nanog Target Gene that Can Substitute for Nanog Function in Pluripotent Cells. Cell Stem Cell 11(4):477-90.
• Chambers I, Silva J, Colby D, Nichols J, Robertson M, Nijmeijer B, Vrana J, Jones K, Grotewold L, Smith A. 2007. Nanog safeguards pluripotency and mediates germ cell development. Nature 450:1230-1234.

Publications

2019

Segregation of the mouse germline and soma. Zhang, Man, and Chambers Ian , Cell Cycle, 2019 Oct 04, p.1-8, (2019)

G2M splits mouse embryonic stem cells into naïve and formative pluripotency states Jääger, Kersti, Simpson D, Kalantzaki Maria, Salzano Angela, Chambers Ian, and Chandra Tamir , BioRxiv, 04/2019, (2019)

Endogenous epitope-tagging of , and identifies TET2 as a naïve pluripotency marker. Pantier, Raphaël, Tatar Tülin, Colby Douglas, and Chambers Ian , Life Sci Alliance, 2019 Oct, Volume 2, Issue 5, (2019)

2018

Esrrb extinction triggers dismantling of naïve pluripotency and marks commitment to differentiation. Festuccia, Nicola, Halbritter Florian, Corsinotti Andrea, Gagliardi Alessia, Colby Douglas, Tomlinson Simon R., and Chambers Ian , EMBO J, 2018 Nov 02, Volume 37, Issue 21, (2018)

OTX2 restricts entry to the mouse germline. Zhang, Jingchao, Zhang Man, Acampora Dario, Vojtek Matúš, Yuan Detian, Simeone Antonio, and Chambers Ian , Nature, 2018 Oct, Volume 562, Issue 7728, p.595-599, (2018)

Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat, Tahsin Stefan, Halbritter Florian, Zhang Man, Rendeiro André F., Perenthaler Elena, Bock Christoph, and Chambers Ian , Cell Stem Cell, 2018 Aug 02, Volume 23, Issue 2, p.276-288.e8, (2018)

Dynamic changes in Sox2 spatio-temporal expression promote the second cell fate decision through/signaling in preimplantation mouse embryos. Mistri, Tapan Kumar, Arindrarto Wibowo, Ng Wei Ping, Wang Choayang, Lim Leng Hiong, Sun Lili, Chambers Ian, Wohland Thorsten, and Robson Paul , Biochem J, 2018 Mar 20, Volume 475, Issue 6, p.1075-1089, (2018)

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells. Zhang, Man, Leitch Harry G., Tang Walfred W. C., Festuccia Nicola, Hall-Ponsele Elisa, Nichols Jennifer, M Surani Azim, Smith Austin, and Chambers Ian , Cell Rep, 2018 Jan 09, Volume 22, Issue 2, p.332-339, (2018)

2017

Functional Antagonism between OTX2 and NANOG Specifies a Spectrum of Heterogeneous Identities in Embryonic Stem Cells. Acampora, Dario, Di Giovannantonio Luca Giovanni, Garofalo Arcomaria, Nigro Vincenzo, Omodei Daniela, Lombardi Alessia, Zhang Jingchao, Chambers Ian, and Simeone Antonio , Stem Cell Reports, 2017 Nov 14, Volume 9, Issue 5, p.1642-1659, (2017)

Distinct SoxB1 networks are required for naïve and primed pluripotency. Corsinotti, Andrea, Wong Frederick Ck, Tatar Tülin, Szczerbinska Iwona, Halbritter Florian, Colby Douglas, Gogolok Sabine, Pantier Raphaël, Liggat Kirsten, Mirfazeli Elham S., et al. , Elife, 2017 12 19, Volume 6, (2017)

A new twist to Sin3 complexes in pluripotent cells. Pantier, Raphaël, Mullin Nicholas P., and Chambers Ian , EMBO J, 2017 Jun 28, (2017)

2016

Distinct Contributions of Tryptophan Residues within the Dimerization Domain to Nanog Function. Mullin, Nicholas P., Gagliardi Alessia, Khoa Le Tran Phuc, Colby Douglas, Hall-Ponsele Elisa, Rowe Arthur J., and Chambers Ian , J Mol Biol, 2017 May 19, (2016)

The pluripotency factor Nanog regulates pericentromeric heterochromatin organization in mouse embryonic stem cells. Novo, Clara Lopes, Tang Calvin, Ahmed Kashif, Djuric Ugljesa, Fussner Eden, Mullin Nicholas P., Morgan Natasha P., Hayre Jasvinder, Sienerth Arnold R., Elderkin Sarah, et al. , Genes Dev, 2016 May 1, Volume 30, Issue 9, p.1101-15, (2016)

Distinct Signaling Requirements for the Establishment of ESC Pluripotency in Late-Stage EpiSCs. Illich, Damir Jacob, Zhang Miao, Ursu Andrei, Osorno Rodrigo, Kim Kee-Pyo, Yoon Juyong, Araúzo-Bravo Marcos J., Wu Guangming, Esch Daniel, Sabour Davood, et al. , Cell Reports, 2016 Apr 14, Issue 15, p.1-14, (2016)

2015

Reprogramming Roadblocks Are System Dependent. Chantzoura, Eleni, Skylaki Stavroula, Menendez Sergio, Kim Shin-Il, Johnsson Anna, Linnarsson Sten, Woltjen Knut, Chambers Ian, and Kaji Keisuke , Stem Cell Reports, 2015 Sep 8, Volume 5, Issue 3, p.350-64, (2015)

Selective influence of Sox2 on POU transcription factor binding in embryonic and neural stem cells. Mistri, Tapan Kumar, Devasia Arun George, Chu Lee Thean, Ng Wei Ping, Halbritter Florian, Colby Douglas, Martynoga Ben, Tomlinson Simon R., Chambers Ian, Robson Paul, et al. , EMBO Rep, 2015 Aug 11, (2015)

Lessons in learning: An effective process for engaging 12- to 14-year-olds in stem cell biology. Kemp, Emma, and Chambers Ian , EMBO Rep, 2015 Jan, Volume 16, Issue 1, p.7-13, (2015)

2014

Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage. Torres-Padilla, Maria-Elena, and Chambers Ian , Development, 2014 Jun, Volume 141, Issue 11, p.2173-81, (2014)

2013

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi, Alessia, Mullin Nicholas P., Tan Zi Ying, Colby Douglas, Kousa Anastasia I., Halbritter Florian, Weiss Jason T., Felker Anastasia, Bezstarosti Karel, Favaro Rebecca, et al. , EMBO J, 2013 Aug 14, Volume 32, Issue 16, p.2231-47, (2013)

The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states. Festuccia, Nicola, Osorno Rodrigo, Wilson Valerie, and Chambers Ian , Curr Opin Genet Dev, 2013 Oct, Volume 23, Issue 5, p.504-11, (2013)

Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity. Zhou, Xinzhi, Smith A G., Waterhouse Anna, Blin Guillaume, Malaguti Mattias, Lin Chia-Yi, Osorno Rodrigo, Chambers Ian, and Lowell Sally , Stem Cells, 2013 Aug, Volume 31, Issue 8, p.1511-22, (2013)

Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Karwacki-Neisius, Violetta, Göke Jonathan, Osorno Rodrigo, Halbritter Florian, Ng Jia Hui, Weiße Andrea Y., Wong Frederick, Gagliardi Alessia, Mullin Nicholas P., Festuccia Nicola, et al. , Cell Stem Cell, 2013 May 2, Volume 12, Issue 5, p.531-45, (2013)

The pluripotent genome in three dimensions is shaped around pluripotency factors. de Wit, Elzo, Bouwman Britta A. M., Zhu Yun, Klous Petra, Splinter Erik, Verstegen Marjon J. A. M., Krijger Peter H. L., Festuccia Nicola, Nora Elphège P., Welling Maaike, et al. , Nature, 2013 Sep 12, Volume 501, Issue 7466, p.227-31, (2013)

2012

OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. Navarro, Pablo, Festuccia Nicola, Colby Douglas, Gagliardi Alessia, Mullin Nicholas P., Zhang Wensheng, Karwacki-Neisius Violetta, Osorno Rodrigo, Kelly David, Robertson Morag, et al. , EMBO J, 2012 Dec 12, Volume 31, Issue 24, p.4547-62, (2012)

Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Festuccia, Nicola, Osorno Rodrigo, Halbritter Florian, Karwacki-Neisius Violetta, Navarro Pablo, Colby Douglas, Wong Frederick, Yates Adam, Tomlinson Simon R., and Chambers Ian , Cell Stem Cell, 2012 Oct 5, Volume 11, Issue 4, p.477-90, (2012)

Stem cell powwow in Squaw Valley Chambers, Ian, and Schroeder Timm , Development, 2012 Jul, Volume 139, Issue 14, p.2457-61, (2012)

The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression. Osorno, Rodrigo, Tsakiridis Anestis, Wong Frederick, Cambray Noemí, Economou Constantinos, Wilkie Ron, Blin Guillaume, Scotting Paul J., Chambers Ian, and Wilson Valerie , Development, 2012 Jul, Volume 139, Issue 13, p.2288-98, (2012)

Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Lavial, Fabrice, Bessonnard Sylvain, Ohnishi Yusuke, Tsumura Akiko, Chandrashekran Anil, Fenwick Mark A., Tomaz Rute A., Hosokawa Hiroyuki, Nakayama Toshinori, Chambers Ian, et al. , Genes Dev, 2012 Jul 1, Volume 26, Issue 13, p.1445-58, (2012)

2011

The Function of Nanog in Pluripotency Mullin, Nicholas P., and Chambers Ian , Nuclear Reprogramming and Stem Cells, (2011)

Transcription factor heterogeneity and epiblast pluripotency. Osorno, Rodrigo, and Chambers Ian , Philos Trans R Soc Lond B Biol Sci, 2011 Aug 12, Volume 366, Issue 1575, p.2230-7, (2011)

The evolving biology of cell reprogramming. Wilmut, Ian, Sullivan Gareth, and Chambers Ian , Philos Trans R Soc Lond B Biol Sci, 2011 Aug 12, Volume 366, Issue 1575, p.2183-97, (2011)

The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells. Navarro, Pablo, Moffat Michael, Mullin Nicholas P., and Chambers Ian , Hum Genet, 2011 Aug, Volume 130, Issue 2, p.255-64, (2011)

Quantification of pluripotency transcription factor levels in embryonic stem cells by flow cytometry. Festuccia, Nicola, and Chambers Ian , Curr Protoc Stem Cell Biol, 2011 Dec, Volume Chapter 1, p.Unit 1B.9, (2011)

2010

Is the umbilical cord a lifeline for regenerative therapy? Navarro, Pablo, and Chambers Ian , Cell Cycle, 2010 Apr 15, Volume 9, Issue 8, p.1464, (2010)

An Oct4-centered protein interaction network in embryonic stem cells. van den Berg, Debbie L. C., Snoek Tim, Mullin Nicholas P., Yates Adam, Bezstarosti Karel, Demmers Jeroen, Chambers Ian, and Poot Raymond A. , Cell Stem Cell, 2010 Apr 2, Volume 6, Issue 4, p.369-81, (2010)

Molecular coupling of Tsix regulation and pluripotency. Navarro, Pablo, Oldfield Andrew, Legoupi Julie, Festuccia Nicola, Dubois Agnès, Attia Mikael, Schoorlemmer Jon, Rougeulle Claire, Chambers Ian, and Avner Philip , Nature, 2010 Nov 18, Volume 468, Issue 7322, p.457-60, (2010)

A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis. Kuijk, Ewart W., de Gier Jeffrey, Lopes Susana M. Chuva de, Chambers Ian, van Pelt Ans M. M., Colenbrander Ben, and Roelen Bernard A. J. , PLoS One, 2010, Volume 5, Issue 6, p.e10987, (2010)

2009

Nanog is the gateway to the pluripotent ground state. Silva, Jose, Nichols Jennifer, Theunissen Thorold W., Guo Ge, van Oosten Anouk L., Barrandon Ornella, Wray Jason, Yamanaka Shinya, Chambers Ian, and Smith Austin , Cell, 2009 Aug 21, Volume 138, Issue 4, p.722-37, (2009)

Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Tsakiridis, Anestis, Tzouanacou Elena, Rahman Afifah, Colby Douglas, Axton Richard A., Chambers Ian, Wilson Valerie, Forrester Lesley M., and Brickman Joshua M. , Nucleic Acids Res, 2009 Oct, Volume 37, Issue 19, p.e129, (2009)

The transcriptional foundation of pluripotency. Chambers, Ian, and Tomlinson Simon R. , Development, 2009 Jul, Volume 136, Issue 14, p.2311-22, (2009)

2008

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. van den Berg, Debbie L. C., Zhang Wensheng, Yates Adam, Engelen Erik, Takacs Katalin, Bezstarosti Karel, Demmers Jeroen, Chambers Ian, and Poot Raymond A. , Mol Cell Biol, 2008 Oct, Volume 28, Issue 19, p.5986-95, (2008)

Molecular coupling of Xist regulation and pluripotency. Navarro, Pablo, Chambers Ian, Karwacki-Neisius Violetta, Chureau Corinne, Morey Céline, Rougeulle Claire, and Avner Philip , Science, 2008 Sep 19, Volume 321, Issue 5896, p.1693-5, (2008)

The pluripotency rheostat Nanog functions as a dimer. Mullin, Nicholas P., Yates Adam, Rowe Arthur J., Nijmeijer Bianca, Colby Douglas, Barlow Paul N., Walkinshaw Malcolm D., and Chambers Ian , Biochem J, 2008 Apr 15, Volume 411, Issue 2, p.227-31, (2008)

2007

Nanog safeguards pluripotency and mediates germline development. Chambers, Ian, Silva Jose, Colby Douglas, Nichols Jennifer, Nijmeijer Bianca, Robertson Morag, Vrana Jan, Jones Ken, Grotewold Lars, and Smith Austin , Nature, 2007 Dec 20, Volume 450, Issue 7173, p.1230-4, (2007)

2006

Nanog promotes transfer of pluripotency after cell fusion. Silva, Jose, Chambers Ian, Pollard Steven M., and Smith Austin , Nature, 2006 Jun 22, Volume 441, Issue 7096, p.997-1001, (2006)

Nanog retrotransposed genes with functionally conserved open reading frames. Robertson, Morag, Stenhouse Frances H., Colby Douglas, Marland Jamie R. K., Nichols Jennifer, Tweedie Susan, and Chambers Ian , Mamm Genome, 2006 Jul, Volume 17, Issue 7, p.732-43, (2006)

2005

The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells. Yates, A, and Chambers Ian , Biochem Soc Trans, 2005 Dec, Volume 33, Issue Pt 6, p.1518-21, (2005)

Characterization of the uterine phenotype during the peri-implantation period for LIF-null, MF1 strain mice. Fouladi-Nashta, A A., Jones C J. P., Nijjar N, Mohamet L, Smith A, Chambers Ian, and Kimber S J. , Dev Biol, 2005 May 1, Volume 281, Issue 1, p.1-21, (2005)

2004

The molecular basis of pluripotency in mouse embryonic stem cells. Chambers, Ian , Cloning Stem Cells, 2004, Volume 6, Issue 4, p.386-91, (2004)

Identification of genes regulated by leukemia-inhibitory factor in the mouse uterus at the time of implantation. Sherwin, J R. A., Freeman T C., Stephens R J., Kimber S J., Smith A G., Chambers Ian, Smith S K., and Sharkey A M. , Mol Endocrinol, 2004 Sep, Volume 18, Issue 9, p.2185-95, (2004)

Self-renewal of teratocarcinoma and embryonic stem cells. Chambers, Ian, and Smith Austin , Oncogene, 2004 Sep 20, Volume 23, Issue 43, p.7150-60, (2004)

2003

Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles. Testa, Giuseppe, Zhang Youming, Vintersten Kristina, Benes Vladimir, Pijnappel W W. M. Pim, Chambers Ian, Smith A G., Smith Austin G., and A Stewart Francis , Nat Biotechnol, 2003 Apr, Volume 21, Issue 4, p.443-7, (2003)

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Chambers, Ian, Colby Douglas, Robertson Morag, Nichols Jennifer, Lee Sonia, Tweedie Susan, and Smith Austin , Cell, 2003 May 30, Volume 113, Issue 5, p.643-55, (2003)

BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Ying, Qi Long, Nichols Jennifer, Chambers Ian, and Smith Austin , Cell, 2003 Oct 31, Volume 115, Issue 3, p.281-92, (2003)

2002

Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells. Niwa, Hitoshi, Masui Shinji, Chambers Ian, Smith Austin G., and Miyazaki Jun-ichi , Mol Cell Biol, 2002 Mar, Volume 22, Issue 5, p.1526-36, (2002)

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Aubert, Jerôme, Dunstan Hannah, Chambers Ian, and Smith Austin , Nat Biotechnol, 2002 Dec, Volume 20, Issue 12, p.1240-5, (2002)

2001

Physiological rationale for responsiveness of mouse embryonic stem cells to gp130 cytokines. Nichols, J, Chambers Ian, Taga T, and Smith A , Development, 2001 Jun, Volume 128, Issue 12, p.2333-9, (2001)

1999

Signaling mechanisms regulating self-renewal and differentiation of pluripotent embryonic stem cells. Burdon, Tom, Chambers Ian, Stracey C, Niwa H, and Smith A , Cells Tissues Organs, 1999, Volume 165, Issue 3-4, p.131-43, (1999)

Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Burdon, Tom, Stracey C, Chambers Ian, Nichols J, and Smith A , Dev Biol, 1999 Jun 1, Volume 210, Issue 1, p.30-43, (1999)

1998

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Niwa, H, Burdon Tom, Chambers Ian, and Smith A , Genes Dev, 1998 Jul 1, Volume 12, Issue 13, p.2048-60, (1998)

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Nichols, J, Zevnik B, Anastassiadis Konstantinos, Niwa H, Klewe-Nebenius D, Chambers Ian, Schöler H, and Smith A , Cell, 1998 Oct 30, Volume 95, Issue 3, p.379-91, (1998)

Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway. Dani, C, Chambers Ian, Johnstone S, Robertson M, Ebrahimi B, Saito M, Taga T, Li M, Burdon Tom, Nichols J, et al. , Dev Biol, 1998 Nov 1, Volume 203, Issue 1, p.149-62, (1998)

1997

Structure of the mouse leukaemia inhibitory factor receptor gene: regulated expression of mRNA encoding a soluble receptor isoform from an alternative 5' untranslated region. Chambers, Ian, Cozens A, Broadbent J, Robertson M, Lee M, Li M, and Smith A , Biochem J, 1997 Dec 15, Volume 328 ( Pt 3), p.879-88, (1997)

1996

Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis. Nichols, J, Davidson D, Taga T, Yoshida K, Chambers Ian, and Smith A , Mech Dev, 1996 Jul, Volume 57, Issue 2, p.123-31, (1996)

1994

Transcriptional up-regulation of the mouse cytosolic glutathione peroxidase gene in erythroid cells is due to a tissue-specific 3' enhancer containing functionally important CACC/GT motifs and binding sites for GATA and Ets transcription factors. O'Prey, J, Ramsay S, Chambers Ian, and Harrison P R. , Mol Cell Biol, 1994 Jan, Volume 14, Issue 1, p.868, (1994)

Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Mountford, P, Zevnik B, Düwel A, Nichols J, Li M, Dani C, Robertson M, Chambers Ian, and Smith A , Proc Natl Acad Sci U S A, 1994 May 10, Volume 91, Issue 10, p.4303-7, (1994)

Derivation of germline competent embryonic stem cells with a combination of interleukin-6 and soluble interleukin-6 receptor. Nichols, J, Chambers Ian, and Smith A , Exp Cell Res, 1994 Nov, Volume 215, Issue 1, p.237-9, (1994)

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways. Yoshida, K, Chambers Ian, Nichols J, Smith A, Saito M, Yasukawa K, Shoyab M, Taga T, and Kishimoto T , Mech Dev, 1994 Feb, Volume 45, Issue 2, p.163-71, (1994)

1993

Expression of alternative forms of differentiation inhibiting activity (DIA/LIF) during murine embryogenesis and in neonatal and adult tissues. Robertson, M, Chambers Ian, Rathjen P D., Nichols J, and Smith A , Dev Genet, 1993, Volume 14, Issue 3, p.165-73, (1993)

1991

Expression of the type 1 human immunodeficiency virus Nef protein in T cells prevents antigen receptor-mediated induction of interleukin 2 mRNA. Luria, S, Chambers Ian, and Berg P , Proc Natl Acad Sci U S A, 1991 Jun 15, Volume 88, Issue 12, p.5326-30, (1991)

1990

Regulation of erythroid-specific gene expression. Harrison, P R., Plumb M, Frampton J, Thiele B, Macleod K, Chester J, Chambers Ian, Fleming J, O'Prey J, and Walker M , Biomed Biochim Acta, 1990, Volume 49, Issue 2-3, p.S5-10, (1990)

1988

cis and trans control of erythroid cell-specific gene expression during erythropoiesis. Harrison, P R., Plumb M, Frampton J, Chambers Ian, Llewellyn D, Chester J, Macleod K, Fleming J, O'Prey J, and Walker M , J Cell Sci Suppl, 1988, Volume 10, p.145-55, (1988)

Effect of selenium status on mRNA levels for glutathione peroxidase in rat liver. Saedi, M S., Smith C G., Frampton J, Chambers Ian, Harrison P R., and Sunde R A. , Biochem Biophys Res Commun, 1988 Jun 16, Volume 153, Issue 2, p.855-61, (1988)

Regulation of erythroid cell-specific gene expression during erythropoiesis. Harrison, P R., Plumb M, Frampton J, Llewellyn D, Chester J, Chambers Ian, Macleod K, Fleming J, O'Prey J, and Walker M , Br J Cancer Suppl, 1988 Dec, Volume 9, p.46-51, (1988)

1987

A new puzzle in selenoprotein biosynthesis: selenocysteine seems to be encoded by the ‘stop’ codon, UGA Chambers, Ian, and Harrison Paul R. , Trends in Biochemical Sciences, Jan-01-1987, Volume 12, p.255 - 256, (1987)

Changes in minor transcripts from the alpha 1 and beta maj globin and glutathione peroxidase genes during erythropoiesis. Frampton, J, Conkie D, Chambers Ian, McBain W, Dexter M, and Harrison P , Nucleic Acids Res, 1987 May 11, Volume 15, Issue 9, p.3671-88, (1987)

1986

The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the 'termination' codon, TGA. Chambers, Ian, Frampton J, Goldfarb P, Affara N, McBain W, and Harrison P R. , EMBO J, 1986 Jun, Volume 5, Issue 6, p.1221-7, (1986)

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