Abdenour Soufi

Position:

Group leader

Telephone:

0131 651 9500

Display email:

Abdenour.Soufi@ed.ac.uk

Biography:

2015: Group leader, Chancellor’s fellow, MRC Centre for Regenerative Medicine, University of Edinburgh, UK.
2010-2014: Postdoc, Prof Ken Zaret lab, Cell and Development Biology Department, Institute for Regenerative Medicine, University of Pennsylvania, US.
2007-2009: Postdoc, Dr Sheela Jayaraman lab, School of Immunity and Infection, University of Birmingham, UK.
2002-2006: PhD, Dr Kevin Gaston and Dr Sheela Jayaraman labs, Department of Biochemistry, University of Bristol, UK.
2002: BSc in Biochemistry and Biotechnology, University of Bristol, UK.

Publications

Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming. Soufi, Abdenour, and Dalton Stephen , Development, 2016 Dec 01, Volume 143, Issue 23, p.4301-4311, (2016)

Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. Soufi, Abdenour, Garcia Meilin Fernandez, Jaroszewicz Artur, Osman Nebiyu, Pellegrini Matteo, and Zaret Kenneth S. , Cell, 2015 Apr 23, Volume 161, Issue 3, p.555-68, (2015)

Mechanisms for enhancing cellular reprogramming. Soufi, Abdenour , Curr Opin Genet Dev, 2014 Apr, Volume 25, p.101-9, (2014)

Facilitators and impediments of the pluripotency reprogramming factors' initial engagement with the genome. Soufi, Abdenour, Donahue Greg, and Zaret Kenneth S. , Cell, 2012 Nov 21, Volume 151, Issue 5, p.994-1004, (2012)

DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers. Soufi, Abdenour, Sawasdichai Anyaporn, Shukla Anshuman, Noy Peter, Dafforn Tim, Smith Corinne, Jayaraman Padma-Sheela, and Gaston Kevin , Nucleic Acids Res, 2010 Nov, Volume 38, Issue 21, p.7513-25, (2010)

CK2 phosphorylation of the PRH/Hex homeodomain functions as a reversible switch for DNA binding. Soufi, Abdenour, Noy Peter, Buckle Malcolm, Sawasdichai Anyaporn, Gaston Kevin, and Jayaraman Padma-Sheela , Nucleic Acids Res, 2009 Jun, Volume 37, Issue 10, p.3288-300, (2009)

PRH/Hex: an oligomeric transcription factor and multifunctional regulator of cell fate. Soufi, Abdenour, and Jayaraman Padma-Sheela , Biochem J, 2008 Jun 15, Volume 412, Issue 3, p.399-413, (2008)

Oligomerisation of the developmental regulator proline rich homeodomain (PRH/Hex) is mediated by a novel proline-rich dimerisation domain. Soufi, Abdenour, Smith Corinne, Clarke Anthony R., Gaston Kevin, and Jayaraman Padma-Sheela , J Mol Biol, 2006 May 12, Volume 358, Issue 4, p.943-62, (2006)

Purification and characterisation of the PRH homeodomain: Removal of the N-terminal domain of PRH increases the PRH homeodomain-DNA interaction. Soufi, Abdenour, Gaston Kevin, and Jayaraman Padma-Sheela , Int J Biol Macromol, 2006 Aug 15, Volume 39, Issue 1-3, p.45-50, (2006)

6 May 2016

16 April 2015